Biodegradable Long-Acting Injectables: Platform Technology and Industrial Challenges

Overview

Journal Handb Exp Pharmacol

Specialty Pharmacology

Date 2023 Apr 14

PMID 37059910

Authors

Marieta Duvnjak

Alessia Villois

Farshad Ramazani

Affiliations

Soon will be listed here.

Abstract

Long-acting injectables have been used to benefit patients with chronic diseases. So far, several biodegradable long-acting platform technologies including drug-loaded polymeric microparticles, implants (preformed and in situ forming), oil-based solutions, and aqueous suspension have been established. In this chapter, we summarize all the marketed technology platforms and discuss their challenges regarding development including but not limited to controlling drug release, particle size, stability, sterilization, scale-up manufacturing, etc. Finally, we discuss important criteria to consider for the successful development of long-acting injectables.

Citing Articles

Patient-Centric Long-Acting Injectable and Implantable Platforms─An Industrial Perspective.

Alidori S, Subramanian R, Holm R Mol Pharm. 2024; 21(9):4238-4258.

PMID: 39160132 PMC: 11372838. DOI: 10.1021/acs.molpharmaceut.4c00665.

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