PGT-A Improved Singleton Live Birth Rate Among All Age Groups of Women Who Underwent Elective Single Blastocyst Transfer: a Single-centre Retrospective Study

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2023 Apr 13

PMID 37055598

Authors

Zetong Zheng

Jifan Tan

Lin Chen

Simin Liu

Canquan Zhou

Yubin Li

Affiliations

Soon will be listed here.

Abstract

Purpose: This study assessed the difference in singleton live birth rate (SLBR) between preimplantation genetic testing for aneuploidy (PGT-A) and non-PGT in patients undergoing elective single frozen blastocyst transfer (eSFBT).

Methods: This retrospective cohort study evaluated 10,701 cycles of eSFBT, including PGT-A (n = 3125) and non-PGT (n = 7576). Cycles were further stratified according to age at retrieval. The main outcome was SLBR; secondary outcomes were clinical pregnancy, conception rates, and multiple live birth rate. Confounders were adjusted using multivariable logistic regression models, and the trend test was performed using the general linear model.

Results: SLBR was negatively correlated with age in the non-PGT group (p-trend < 0.001) but not in PGT-A group (p-trend = 0.974). Stratified by the age, SLBR were significantly different between two groups except for the 20-24-year-old group: PGT-A vs non-PGT group in 20-24, 25-29, 30-34, 35-39 and ≥ 40-year-old subgroups were, 53.5% vs 53.2%, 53.5% vs 48.0%, 53.5% vs 43.1%, 53.3% vs 32.5%, and 42.9% vs 17.6%, respectively. In addition, after adjusting for potential confounders, SLBR still remained significantly different in all age groups except in the youngest quartile (PGT-A vs non-PGT group, 20-24: adjusted odds ratio (aOR), 1.33, 95% CI, 0.92-1.92, p = 0.129; 25-29: aOR, 1.32, 95% CI, 1.14-1.52, p < 0.001; 30-34: aOR, 1.91, 95% CI, 1.65-2.20, p < 0.001; 35-39: aOR, 2.50, 95% CI, 1.97-3.17, p < 0.001; ≥ 40: aOR, 3.54, 95% CI, 1.66-7.55, p = 0.001).

Conclusion: PGT-A might improve SLBR among all age groups and play an increasingly important role in SLBR in older patients who underwent eSFBT.

Citing Articles

Beyond appearance: Can morphologically low-grade euploid blastocysts yield successful pregnancies?.

Suzuki T, Ishida C, Yoshioka Y, Kojima M, Tokoro M, Fukunaga N Reprod Med Biol. 2024; 23(1):e12560.

PMID: 38249352 PMC: 10797159. DOI: 10.1002/rmb2.12560.

Sociocultural imperatives for Singapore to permit preimplantation genetic testing-aneuploidy (PGT-A) despite uncertain results and ongoing controversy.

Chin A, Sun N J Assist Reprod Genet. 2023; 40(6):1377-1379.

PMID: 37256530 PMC: 10310662. DOI: 10.1007/s10815-023-02836-6.

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