The Effect of High-Intensity Interval Training on Exercise Capacity in Patients with Coronary Artery Disease: A Systematic Review and Meta-Analysis

Overview

Journal Cardiol Res Pract

Publisher Wiley

Specialty Cardiology & Vascular Diseases

Date 2023 Apr 13

PMID 37050938

Authors

Siyi Li

Xiankun Chen

Huachen Jiao

Yan Li

Guanghui Pan

Xue Yitao

Affiliations

Soon will be listed here.

Abstract

Background: The optimal exercise prescription for coronary artery disease (CAD) remains under debate. The aim of our meta-analysis is to investigate the efficacy of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) of coronary artery disease patients.

Methods: Electronic databases were searched from their inception date until October 23, 2021, and the articles include randomized controlled trials. The mean differences and 95% confidence intervals were calculated, and heterogeneity was assessed using the test.

Results: The study standards were met by seventeen studies. The pooled studies included 902 patients. HIIT resulted in improvement in peak oxygen uptake (1.50 ml/kg/min, 95% confidence interval: 0.48 to 2.53, = 853 patients, and low quality evidence) compared with MICT. There was no discernible difference between the individuals in the HIIT group and the MICT group in terms of systolic/diastolic blood pressure or peak/resting heart rate.

Conclusion: This systematic review and meta-analysis reported the superiority of HIIT versus MICT in enhancing peak oxygen uptake in CAD patients.

Citing Articles

Effects of high-intensity interval training versus moderate-intensity continuous training on cardiorespiratory and exercise capacity in patients with coronary artery disease: A systematic review and meta-analysis.

Gao C, Yue Y, Wu D, Zhang J, Zhu S PLoS One. 2025; 20(2):e0314134.

PMID: 39977401 PMC: 11841918. DOI: 10.1371/journal.pone.0314134.

The effects of high-intensity interval training and moderate-intensity continuous training on patients underwent Coronary Artery Bypass Graft surgery; a systematic review.

Chichagi F, Alikhani R, Hosseini M, Azadi K, Shirsalimi N, Ghodsi S Am J Cardiovasc Dis. 2025; 14(6):306-317.

PMID: 39839564 PMC: 11744220. DOI: 10.62347/EWMH1925.

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