Design, Synthesis, and Biological Activities of Novel 2-Cyanoacrylate Compounds Containing Substituted Pyrazolyl or 1,2,3-Triazolyl Moiety

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Apr 13

PMID 37049903

Authors

Yang Wang

Yudie Chen

Ye Qian

Jia Chen

Xianchao Du

Yujun Shi

Baolin Xu

Sheng Hua

Hong Dai

Affiliations

Soon will be listed here.

Abstract

To develop novel 2-cyanoacrylate derivatives with potential bioactivity, a number of 2-cyanoacrylate compounds, including substituted pyrazole or 1,2,3-triazole ring, were designed, prepared, and structurally detected by H NMR, C NMR, and elemental analysis. The biological assessment displayed that some designed compounds had significant herbicidal activities against , , , , and at a dosage of 1500 g/ha. Furthermore, some derivatives still expressed satisfactory herbicidal activities against , and when the dosage was lowered to 150 g/ha, especially the inhibitory effects of compounds , , , , , , , and against were all over 80%, compounds , , , , , , , , , and possessed more than 70% inhibition rates against , and compound indicated 70% herbicidal activity against . These results provided an important basis for further design and discovery of biologically active 2-cyanoacrylate compounds.

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