Magnesium in Kidney Function and Disease-Implications for Aging and Sex-A Narrative Review

Overview

Journal Nutrients

Date 2023 Apr 13

PMID 37049550

Authors

Maria Del Carmen Macias Ruiz

Lorena Cuenca Bermejo

Nicola Veronese

Emiliano Fernandez Villalba

Ana Maria Gonzalez Cuello

Karolina Kublickiene

Valeria Raparelli

Colleen M Norris

Alexandra Kautzky-Willer

Louise Pilote

Mario Barbagallo

Ligia Dominguez

Maria Trinidad Herrero

Affiliations

Soon will be listed here.

Abstract

Magnesium (Mg) has a vital role in the human body, and the kidney is a key organ in the metabolism and excretion of this cation. The objective of this work is to compile the available evidence regarding the role that Mg plays in health and disease, with a special focus on the elderly population with chronic kidney disease (CKD) and the eventual sex differences. A narrative review was carried out by executing an exhaustive search in the PubMed, Scopus, and Cochrane databases. Ten studies were found in which the role of Mg and sex was evaluated in elderly patients with CKD in the last 10 years (2012-2022). The progression of CKD leads to alterations in mineral metabolism, which worsen as the disease progresses. Mg can be used as a coadjuvant in the treatment of CKD patients to improve glomerular filtration, but its use in clinical applications needs to be further characterized. In conclusion, there's a need for well-designed prospective clinical trials to advise and standardize Mg supplementation in daily clinical practice, taking age and sex into consideration.

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