Role of MicroRNAs in Congenital Diaphragmatic Hernia-Associated Pulmonary Hypertension

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Apr 13

PMID 37047629

Authors

Flaminia Pugnaloni

Irma Capolupo

Neil Patel

Paola Giliberti

Andrea Dotta

Pietro Bagolan

Florian Kipfmueller

Affiliations

Soon will be listed here.

Abstract

Epigenetic regulators such as microRNAs (miRNAs) have a key role in modulating several gene expression pathways and have a role both in lung development and function. One of the main pathogenetic determinants in patients with congenital diaphragmatic hernia (CDH) is pulmonary hypertension (PH), which is directly related to smaller lung size and pulmonary microarchitecture alterations. The aim of this review is to highlight the importance of miRNAs in CDH-related PH and to summarize the results covering this topic in animal and human CDH studies. The focus on epigenetic modulators of CDH-PH offers the opportunity to develop innovative diagnostic tools and novel treatment modalities, and provides a great potential to increase researchers' understanding of the pathophysiology of CDH.

Citing Articles

Hemodynamic management of congenital diaphragmatic hernia: the role of targeted neonatal echocardiography.

Surak A, Mahgoub L, Ting J World J Pediatr Surg. 2024; 7(2):e000790.

PMID: 38737963 PMC: 11086387. DOI: 10.1136/wjps-2024-000790.

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