Mucosal Vaccines for SARS-CoV-2: Scientific Gaps and Opportunities-workshop Report

Madhavan M, Ritchie A, Aboagye J, Jenkin D, Provstgaad-Morys S, Tarbet I . Tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine: An open-label partially-randomised ascending dose phase I trial. EBioMedicine. 2022; 85:104298. PMC: 9550199. DOI: 10.1016/j.ebiom.2022.104298. View

Hassan A, Shrihari S, Gorman M, Ying B, Yuan D, Raju S . An intranasal vaccine durably protects against SARS-CoV-2 variants in mice. Cell Rep. 2021; 36(4):109452. PMC: 8270739. DOI: 10.1016/j.celrep.2021.109452. View

Walensky R, Walke H, Fauci A . SARS-CoV-2 Variants of Concern in the United States-Challenges and Opportunities. JAMA. 2021; 325(11):1037-1038. PMC: 9009864. DOI: 10.1001/jama.2021.2294. View

Klick B, Nishiura H, Leung G, Cowling B . Optimal design of studies of influenza transmission in households. II: comparison between cohort and case-ascertained studies. Epidemiol Infect. 2013; 142(4):744-52. PMC: 3883904. DOI: 10.1017/S0950268813001623. View

Rapeport G, Smith E, Gilbert A, Catchpole A, McShane H, Chiu C . SARS-CoV-2 Human Challenge Studies - Establishing the Model during an Evolving Pandemic. N Engl J Med. 2021; 385(11):961-964. DOI: 10.1056/NEJMp2106970. View

Shakya A, Chowdhury M, Tao W, Gill H . Mucosal vaccine delivery: Current state and a pediatric perspective. J Control Release. 2016; 240:394-413. PMC: 5381653. DOI: 10.1016/j.jconrel.2016.02.014. View

Waltz E . China and India approve nasal COVID vaccines - are they a game changer?. Nature. 2022; 609(7927):450. DOI: 10.1038/d41586-022-02851-0. View

Marcelin J, Pettifor A, Janes H, Brown E, Kublin J, Stephenson K . COVID-19 Vaccines and SARS-CoV-2 Transmission in the Era of New Variants: A Review and Perspective. Open Forum Infect Dis. 2022; 9(5):ofac124. PMC: 8992234. DOI: 10.1093/ofid/ofac124. View

Yoshida M, Worlock K, Huang N, Lindeboom R, Butler C, Kumasaka N . Local and systemic responses to SARS-CoV-2 infection in children and adults. Nature. 2021; 602(7896):321-327. PMC: 8828466. DOI: 10.1038/s41586-021-04345-x. View

10.

Port J, Yinda C, Owusu I, Holbrook M, Fischer R, Bushmaker T . SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters. Nat Commun. 2021; 12(1):4985. PMC: 8371001. DOI: 10.1038/s41467-021-25156-8. View

11.

Swadling L, Diniz M, Schmidt N, Amin O, Chandran A, Shaw E . Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2. Nature. 2021; 601(7891):110-117. PMC: 8732273. DOI: 10.1038/s41586-021-04186-8. View

12.

Freeman D, Lambe S, Yu L, Freeman J, Chadwick A, Vaccari C . Injection fears and COVID-19 vaccine hesitancy. Psychol Med. 2021; 53(4):1185-1195. PMC: 8220023. DOI: 10.1017/S0033291721002609. View

13.

Wang R, Hozumi Y, Yin C, Wei G . Decoding SARS-CoV-2 Transmission and Evolution and Ramifications for COVID-19 Diagnosis, Vaccine, and Medicine. J Chem Inf Model. 2020; 60(12):5853-5865. PMC: 7318555. DOI: 10.1021/acs.jcim.0c00501. View

14.

Hapfelmeier S, Lawson M, Slack E, Kirundi J, Stoel M, Heikenwalder M . Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses. Science. 2010; 328(5986):1705-9. PMC: 3923373. DOI: 10.1126/science.1188454. View

15.

Kingstad-Bakke B, Lee W, Chandrasekar S, Gasper D, Salas-Quinchucua C, Cleven T . Vaccine-induced systemic and mucosal T cell immunity to SARS-CoV-2 viral variants. Proc Natl Acad Sci U S A. 2022; 119(20):e2118312119. PMC: 9171754. DOI: 10.1073/pnas.2118312119. View

16.

Krause P, Arora N, Dowling W, Munoz-Fontela C, Funnell S, Gaspar R . Making more COVID-19 vaccines available to address global needs: Considerations and a framework for their evaluation. Vaccine. 2022; 40(40):5749-5751. PMC: 9343170. DOI: 10.1016/j.vaccine.2022.07.028. View

17.

Mao T, Israelow B, Pena-Hernandez M, Suberi A, Zhou L, Luyten S . Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses. Science. 2022; 378(6622):eabo2523. PMC: 9798903. DOI: 10.1126/science.abo2523. View

18.

Tang J, Zeng C, Cox T, Li C, Son Y, Cheon I . Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination. Sci Immunol. 2022; 7(76):eadd4853. PMC: 9348751. DOI: 10.1126/sciimmunol.add4853. View

19.

Stephenson E, Reynolds G, Botting R, Calero-Nieto F, Morgan M, Tuong Z . Single-cell multi-omics analysis of the immune response in COVID-19. Nat Med. 2021; 27(5):904-916. PMC: 8121667. DOI: 10.1038/s41591-021-01329-2. View

20.

Sheikh-Mohamed S, Isho B, Chao G, Zuo M, Cohen C, Lustig Y . Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection. Mucosal Immunol. 2022; 15(5):799-808. PMC: 9037584. DOI: 10.1038/s41385-022-00511-0. View