Extracellular Vesicle-mediated Remodeling of the Bone Marrow Microenvironment in Myeloid Malignancies

Overview

Journal Int J Hematol

Specialty Hematology

Date 2023 Apr 11

PMID 37041345

Authors

Yasutaka Hayashi

Koutarou Nishimura

Atsushi Tanaka

Daichi Inoue

Affiliations

Soon will be listed here.

Abstract

Hematopoiesis is maintained and regulated by a bone marrow-specific microenvironment called a niche. In hematological malignancies, tumor cells induce niche remodeling, and the reconstructed niche is closely linked to disease pathogenesis. Recent studies have suggested that extracellular vesicles (EVs) secreted from tumor cells play a principal role in niche remodeling in hematological malignancies. Although EVs are emerging as potential therapeutic targets, the underlying mechanism of action remains unclear, and selective inhibition remains a challenge. This review summarizes remodeling of the bone marrow microenvironment in hematological malignancies and its contribution to pathogenesis, as well as roles of tumor-derived EVs, and provides a perspective on future research in this field.

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