Furan Donor for NIR-II Molecular Fluorophores with Enhanced Bioimaging Performance

Overview

Journal Research (Wash D C)

Specialty Biology

Date 2023 Apr 11

PMID 37040521

Authors

Chunchen Liu

Mengfei Li

Huilong Ma

Zhubin Hu

Xinyuan Wang

Rui Ma

Yingying Jiang

Haitao Sun

Shoujun Zhu

Yongye Liang

Affiliations

Soon will be listed here.

Abstract

The second near-infrared (NIR-II, 1,000 to 1,700 nm) molecular fluorophores containing donor-acceptor-donor conjugated backbone have attracted substantial attention due to their outstanding advantages, such as stable emission and facilely tuned photophysical properties. However, it is still challenging for them to simultaneously achieve high brightness and red-shifted absorption and emission. Herein, furan is adopted as the D unit to construct NIR-II fluorophores, demonstrating red shift of absorption, enhanced absorption coefficient, and fluorescent quantum yield when compared with the generally used thiophene counterparts. The high brightness and desirable pharmacokinetics of the optimized fluorophore, IR-FFCHP, endows improved performance for angiography and tumor-targeting imaging. Furthermore, dual-NIR-II imaging of tumor and sentinel lymph nodes (LNs) has been achieved with IR-FFCHP and PbS/CdS quantum dots, enabling the in vivo imaging navigated LN surgery in tumor-bearing mice. This work demonstrates the potential of furan for constructing bright NIR-II fluorophores for biological imaging.

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