Nanoparticles Coated by Chloramphenicol in Hydrogels As a Useful Tool to Increase the Antibiotic Release and Antibacterial Activity in Dermal Drug Delivery

Overview

Journal Pharmacol Rep

Specialty Pharmacology

Date 2023 Apr 11

PMID 37039973

Authors

Dawid Bursy

Radoslaw Balwierz

Pawel Groch

Pawel Biernat

Adam Byrski

Katarzyna Kasperkiewicz

Wioletta Ochedzan-Siodlak

Affiliations

Soon will be listed here.

Abstract

Background: Nanocarriers for antibacterial drugs became hopeful tools against the increasing resistance of bacteria to antibiotics. This work focuses on a comprehensive study of the applicability and therapeutic suitability of dermal carbopol-based hydrogels containing chloramphenicol carried by various nanoparticles (AuNPs and SiNPs).

Methods: The different forms of carbopol-based drugs for dermal use were obtained. Five different concentrations of chloramphenicol and two types of nanoparticles (silica and gold) in carbopol-based ointments were tested. The influence of different carbopol formulations with nanocarriers on the rheological properties as well as the release profile of active substances and bacteriostatic activity on five reference strains were determined.

Results: The properties of the obtained hydrogels were compared to a commercial formulation, and finally it was possible to obtain a formulation that allowed improved antimicrobial activity over a commercially available detreomycin ointment while reducing the concentration of the antibiotic.

Conclusion: The work indicates that it is possible to reduce the concentration of chloramphenicol by four times while maintaining its bacteriostatic activity, which can improve the patient's safety profile while increasing the effectiveness of the therapy.

Citing Articles

Development and Characterization of a Hydrogel Containing Chloramphenicol-Loaded Binary Ethosomes for Effective Transdermal Permeation and Treatment Acne in Rat Model.

Liu R, Li M, Zhu Q, Liu H, Zhang X, Han X Int J Nanomedicine. 2025; 20:1697-1715.

PMID: 39931531 PMC: 11809363. DOI: 10.2147/IJN.S476937.

Progress in Topical and Transdermal Drug Delivery Research-Focus on Nanoformulations.

Lunter D, Klang V, Eichner A, Savic S, Savic S, Lian G Pharmaceutics. 2024; 16(6).

PMID: 38931938 PMC: 11207871. DOI: 10.3390/pharmaceutics16060817.

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