Cholesterol- and Actin-centered View of the Plasma Membrane: Updating the Singer-Nicolson Fluid Mosaic Model to Commemorate Its 50th Anniversary

Overview

Journal Mol Biol Cell

Specialties Cell Biology
Molecular Biology

Date 2023 Apr 11

PMID 37039596

Authors

Akihiro Kusumi

Taka A Tsunoyama

Bo Tang

Koichiro M Hirosawa

Nobuhiro Morone

Takahiro K Fujiwara

Kenichi G N Suzuki

Affiliations

Soon will be listed here.

Abstract

Two very polarized views exist for understanding the cellular plasma membrane (PM). For some, it is the simple fluid described by the original Singer-Nicolson fluid mosaic model. For others, due to the presence of thousands of molecular species that extensively interact with each other, the PM forms various clusters and domains that are constantly changing and therefore, no simple rules exist that can explain the structure and molecular dynamics of the PM. In this article, we propose that viewing the PM from its two predominant components, cholesterol and actin filaments, provides an excellent and transparent perspective of PM organization, dynamics, and mechanisms for its functions. We focus on the actin-induced membrane compartmentalization and lipid raft domains coexisting in the PM and how they interact with each other to perform PM functions. This view provides an important update of the fluid mosaic model.

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