Minimally Invasive Bioprinting for Liver Regeneration

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2023 Apr 10

PMID 37035761

Authors

Yueying Yang

Zhengyang Yu

Xiaohuan Lu

Jiahao Dai

Cheng Zhou

Jing Yan

Lin Wang

Zheng Wang

Jianfeng Zang

Affiliations

Soon will be listed here.

Abstract

bioprinting is promising for developing scaffolds directly on defect models in operating rooms, which provides a new strategy for tissue regeneration. However, due to the limitation of existing biofabrication technologies including printing depth and suitable bioinks, bioprinting scaffolds in deep dermal or extremity injuries remains a grand challenge. Here, we present an scaffold fabrication approach by minimally invasive bioprinting electroactive hydrogel scaffolds to promote tissue regeneration. The minimally invasive bioprinting system consists of a ferromagnetic soft catheter robot for extrusion, a digital laparoscope for monitoring, and a Veress needle for establishing a pneumoperitoneum. After 3D reconstruction of the defects with computed tomography, electroactive hydrogel scaffolds are printed within partial liver resection of live rats, and tissue regeneration is achieved by promoting the proliferation, migration, and differentiation of cells and maintaining liver function .

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