Hyperconnectivity of Two Separate Long-range Cholinergic Systems Contributes to the Reorganization of the Brain Functional Connectivity During Nicotine Withdrawal in Male Mice

Overview

Journal bioRxiv

Date 2023 Apr 10

PMID 37034602

Authors

Lieselot L G Carrette

Adam Kimbrough

Pasha A Davoudian

Alex C Kwan

Andres Collazo

Olivier George

Affiliations

Soon will be listed here.

Abstract

Significance Statement: Discontinuation of nicotine use in dependent users is associated with increased whole-brain activation and functional connectivity and leads to withdrawal symptoms. Here we investigated the contribution of the nicotinic cholinergic receptors and main cholinergic projecting brain areas in the whole-brain changes associated with withdrawal. This not only allowed us to visualize and confirm the previously described duality of the cholinergic brain system using this novel methodology, but also identify nicotinic receptors together with 1751 other genes that contribute, and could thus be targets for treatments against, nicotine withdrawal and dependence.

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