Menopause and Women's Cardiovascular Health: is It Really an Obvious Relationship?

Overview

Journal Arch Med Sci

Specialty General Medicine

Date 2023 Apr 10

PMID 37034510

Authors

Kamila Ryczkowska

Weronika Adach

Kamil Janikowski

Maciej Banach

Agata Bielecka-Dabrowa

Affiliations

Soon will be listed here.

Abstract

Cardiovascular diseases are common for men and women but there are differences between the sexes in terms of clinical symptoms, pathophysiology and response to the treatment. Cardiovascular diseases (CVD) in women is commonly underdiagnosed and often women tend to have a lower perception of the risk. That can lead to delayed diagnosis and failed recognition of symptoms. Women develop heart diseases later than men because of the protection in the reproductive phase of their life. Once they enter menopause the risk increases. Estrogen provides a protective effect against heart disease in women. Therefore, the risk of CVD increases after menopause in most cases. The presented work emphasizes the importance of the menopausal period as the time of increasing CVD risk. It also emphasizes the importance of monitoring the health of women in their middle age, a critical time in which early intervention strategies should be implemented to reduce the risk of CVD.

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References

Zhu D, Chung H, Dobson A, Pandeya N, Giles G, Bruinsma F . Age at natural menopause and risk of incident cardiovascular disease: a pooled analysis of individual patient data. Lancet Public Health. 2019; 4(11):e553-e564. PMC: 7118366. DOI: 10.1016/S2468-2667(19)30155-0. View

Hu J, Zhang Z, Shen W, Azhar S . Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones. Nutr Metab (Lond). 2010; 7:47. PMC: 2890697. DOI: 10.1186/1743-7075-7-47. View

Nikolic D, Banach M, Mikhailidis D, Rizzo M . Can the effects of gender, menopause and ageing on lipid levels be differentiated?. Clin Endocrinol (Oxf). 2016; 85(5):694-695. DOI: 10.1111/cen.13159. View

Mauvais-Jarvis F, Manson J, Stevenson J, Fonseca V . Menopausal Hormone Therapy and Type 2 Diabetes Prevention: Evidence, Mechanisms, and Clinical Implications. Endocr Rev. 2017; 38(3):173-188. PMC: 5460681. DOI: 10.1210/er.2016-1146. View

Oliver-Williams C, Glisic M, Shahzad S, Brown E, Baena C, Chadni M . The route of administration, timing, duration and dose of postmenopausal hormone therapy and cardiovascular outcomes in women: a systematic review. Hum Reprod Update. 2018; 25(2):257-271. DOI: 10.1093/humupd/dmy039. View

Cui J, Shen Y, Li R . Estrogen synthesis and signaling pathways during aging: from periphery to brain. Trends Mol Med. 2013; 19(3):197-209. PMC: 3595330. DOI: 10.1016/j.molmed.2012.12.007. View

El Khoudary S . Gaps, limitations and new insights on endogenous estrogen and follicle stimulating hormone as related to risk of cardiovascular disease in women traversing the menopause: A narrative review. Maturitas. 2017; 104:44-53. DOI: 10.1016/j.maturitas.2017.08.003. View

Stuenkel C, Davis S, Gompel A, Lumsden M, Murad M, Pinkerton J . Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015; 100(11):3975-4011. DOI: 10.1210/jc.2015-2236. View

Iorga A, Cunningham C, Moazeni S, Ruffenach G, Umar S, Eghbali M . The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy. Biol Sex Differ. 2017; 8(1):33. PMC: 5655818. DOI: 10.1186/s13293-017-0152-8. View

10.

Taneja C, Gera S, Kim S, Iqbal J, Yuen T, Zaidi M . FSH-metabolic circuitry and menopause. J Mol Endocrinol. 2019; 63(3):R73-R80. PMC: 6992500. DOI: 10.1530/JME-19-0152. View

11.

Hallajzadeh J, Khoramdad M, Izadi N, Karamzad N, Almasi-Hashiani A, Ayubi E . Metabolic syndrome and its components in premenopausal and postmenopausal women: a comprehensive systematic review and meta-analysis on observational studies. Menopause. 2018; 25(10):1155-1164. DOI: 10.1097/GME.0000000000001136. View

12.

Katsiki N, Banach M . Statins and the risk of diabetes: the debate. Arch Intern Med. 2012; 172(11):895-6. DOI: 10.1001/archinternmed.2012.1240. View

13.

Bielecka-Dabrowa A, Bartlomiejczyk M, Sakowicz A, Maciejewski M, Banach M . The Role of Adipokines in the Development of Arterial Stiffness and Hypertension. Angiology. 2020; 71(8):754-761. DOI: 10.1177/0003319720927203. View

14.

Ji H, Kim A, Ebinger J, Niiranen T, Claggett B, Merz C . Sex Differences in Blood Pressure Trajectories Over the Life Course. JAMA Cardiol. 2020; 5(3):19-26. PMC: 6990675. DOI: 10.1001/jamacardio.2019.5306. View

15.

Bojar I, Raczkiewicz D, Gujski M, Humeniuk E, Wdowiak A, Owoc A . Oestrogen receptor α gene polymorphisms, insomnia, and cognitive functions in perimenopausal and postmenopausal women in non-manual employment. Arch Med Sci. 2022; 18(5):1318-1328. PMC: 9479593. DOI: 10.5114/aoms.2020.94977. View

16.

Paduszynska A, Sakowicz A, Banach M, Maciejewski M, Dabrowa M, Bielecka-Dabrowa A . Cardioprotective properties of leptin in patients with excessive body mass. Ir J Med Sci. 2020; 189(4):1259-1265. PMC: 7554003. DOI: 10.1007/s11845-020-02211-9. View

17.

Greendale G, Sternfeld B, Huang M, Han W, Karvonen-Gutierrez C, Ruppert K . Changes in body composition and weight during the menopause transition. JCI Insight. 2019; 4(5). PMC: 6483504. DOI: 10.1172/jci.insight.124865. View

18.

Yan X, Jin J, Hong L, Guo Y, Wu N, Zhu C . Lipoprotein(a) Is Associated with the Presence and Severity of New-Onset Coronary Artery Disease in Postmenopausal Women. J Womens Health (Larchmt). 2020; 29(4):503-510. DOI: 10.1089/jwh.2019.7773. View

19.

El Khoudary S, Thurston R . Cardiovascular Implications of the Menopause Transition: Endogenous Sex Hormones and Vasomotor Symptoms. Obstet Gynecol Clin North Am. 2018; 45(4):641-661. DOI: 10.1016/j.ogc.2018.07.006. View

20.

El Khoudary S, Aggarwal B, Beckie T, Hodis H, Johnson A, Langer R . Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association. Circulation. 2020; 142(25):e506-e532. DOI: 10.1161/CIR.0000000000000912. View