High-density Lipoprotein Cholesterol Levels is Negatively Associated with Intertrochanter Bone Mineral Density in Adults Aged 50 Years and Older

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2023 Apr 10

PMID 37033266

Authors

Pei Yang

Dongdong Li

Xiaokang Li

Zongbiao Tan

Huan Wang

Xiaona Niu

Yang Han

Cheng Lian

Affiliations

Soon will be listed here.

Abstract

Background: High-density lipoprotein cholesterol (HDL-C) has long been viewed as a protective factor for cardiovascular health. Yet, higher HDL-C was not necessarily beneficial. The purpose of this study was to investigate the relationship between HDL-C levels and intertrochanter bone mineral density.

Methods: The study collected the most recent data from the 2017-2020 National Health and Nutrition Examination Survey (NHANES). Weighted multiple regression analysis was used to evaluate the relationship between HDL-C and intertrochanter BMD, and further subgroup analysis and threshold effect analysis were conducted. Finally, the relationship between HDL-C and intertrochanter BMD was analyzed by fitting smooth curves.

Results: The study included 3,345 people ranging in age from 50 to 80. HDL-C was discovered to be negatively correlated with intertrochanter BMD (β = -0.03, 95%CI: -0.04, -0.01, = 0.0002). In subgroup analysis, the negative correlation was found among 60-70-year-olds (β = -0.04, 95%CI: -0.06, -0.02, = 0.0010), additionally, non-Hispanic whites (β = -0.03, 95%CI: -0.05, -0.01, = 0.0140), and obese individuals (β = -0.03, 95%CI: -0.05, -0.01, = 0.0146). The negative correlation, on the other hand, remained significant and consistent across genders, menstruation status, hormone usage, and long-term use of steroids. The relationship between HDL-C and intertrochanter BMD was an inverted U-shaped curve in men and hormone users, with inflection points of 1.01 mmol/L and 1.71 mmol/L, and an U-shaped curve in other Hispanic and premenopausal individuals, with inflection points of 0.96 mmol/L and 1.89 mmol/L.

Conclusions: HDL-C was negatively associated with intertrochanter BMD in people over 50 years of age, non-Hispanic whites, and obesity.

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