New Uses for an Old Remedy: Digoxin As a Potential Treatment for Steatohepatitis and Other Disorders

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2023 Apr 10

PMID 37032732

Authors

Fatima Jamshed

Farzaneh Dashti

Xinshou Ouyang

Wajahat Z Mehal

Bubu A Banini

Affiliations

Soon will be listed here.

Abstract

Repurposing of the widely available and relatively cheap generic cardiac gly-coside digoxin for non-cardiac indications could have a wide-ranging impact on the global burden of several diseases. Over the past several years, there have been significant advances in the study of digoxin pharmacology and its potential non-cardiac clinical applications, including anti-inflammatory, antineoplastic, metabolic, and antimicrobial use. Digoxin holds promise in the treatment of gastrointestinal disease, including nonalcoholic steatohepatitis and alcohol-associated steatohepatitis as well as in obesity, cancer, and treatment of viral infections, among other conditions. In this review, we provide a summary of the clinical uses of digoxin to date and discuss recent research on its emerging applications.

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