Subcellular Distributions of Calcium/calmodulin-stimulated and Guanine Nucleotide-regulated Adenylate Cyclase Activities in the Cerebral Cortex

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1986 Mar 1

PMID 3703110

Authors

S T Bissen

T Ueda

Affiliations

Soon will be listed here.

Abstract

The subcellular distribution of Ca2+/calmodulin-stimulated adenylate cyclase activity was studied in comparison with that of guanine nucleotide-stimulated cyclase activity. The distributions of these activities were similar among the crude fractions but differed among the purified subsynaptosomal fractions. The specific activity of Ca2+/calmodulin-stimulated cyclase was highest in a light synaptic membrane fraction, which has few, if any, postsynaptic densities, whereas that of guanine nucleotide-stimulated cyclase was highest in a heavier synaptic membrane fraction rich in postsynaptic densities. These results suggest that the Ca2+/calmodulin-stimulated cyclase has, at least in part, a different cellular or subcellular location than the guanine nucleotide-stimulated cyclase.

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