Transbronchial Lung Cryobiopsy and Pulmonary Fibrosis: A Never-ending Story?

Overview

Journal Heliyon

Specialty Social Sciences

Date 2023 Apr 7

PMID 37025914

Authors

Barbara Ruaro

Stefano Tavano

Paola Confalonieri

Riccardo Pozzan

Michael Hughes

Luca Braga

Maria Concetta Volpe

Giovanni Ligresti

Alessia Giovanna Andrisano

Selene Lerda

Pietro Geri

Marco Biolo

Elisa Baratella

Marco Confalonieri

Francesco Salton

Affiliations

Soon will be listed here.

Abstract

Background: The diagnostic process of pulmonary fibrosis (PF) is often challenging, requires a collaborative effort of several experts, and often requires bioptic material, which can be difficult to obtain, both in terms of quality and technique. The main procedures available to obtain such samples are transbronchial lung cryobiopsy (TBLC) and surgical lung biopsy (SLB).

Objective: The purpose of this paper is to review the evidence for the role of TBLC in the diagnostic-therapeutic process of PF.

Methods: A comprehensive review was performed to identify articles to date that addressed the role of TBLC in the diagnostic-therapeutic process of PF using the PubMed® database.

Results: The reasoned search identified 206 papers, including 21 manuscripts (three reviews, one systematic review, two guidelines, two prospective studies, three retrospective studies, one cross-sectional study, one original article, three editorials, three clinical trials, and two unclassifiable studies), which were included in the final review.

Conclusions: TBLC is gaining increasing efficacy and improving safety profile; however, there are currently no clear data demonstrating its superiority over SLB. Therefore, the two techniques should be considered with careful rationalization on a case-by-case basis. Further research is needed to further optimize and standardize the procedure and to thoroughly study the histological and molecular characteristics of PF.

Citing Articles

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