A Brief Review of the Monkeypox Virus and Emerging Concerns for Neuroinvasiveness

Overview

Journal Surg Neurol Int

Specialty Neurology

Date 2023 Apr 7

PMID 37025545

Authors

Atul Anand

Anand Kumar Das

Sona Bhardwaj

Saraj Kumar Singh

Affiliations

Soon will be listed here.

Abstract

Background: Amidst the ongoing COVID-19 pandemic, monkeypox virus (MPXV) disease has been recognized as another disease of pandemic nature by the World Health Organization. Nearly four decades after the eradication of smallpox, as half of the world population is naïve to ortho-pox viruses (supposedly due to lack of immunity by vaccination), MPXV remains the most pathogenic species of the family of poxviruses.

Methods: The articles on MPXV were searched on PubMed/Medline and data were retrieved and analyzed.

Results: Alhough reported as a disease of milder exanthem and lower mortality as compared to smallpox, the MPXV disease tends to be neuroinvasive. This article highlights the neurological signs and symptoms of MPXV disease and discusses, in brief, the management strategies.

Conclusion: Neuroinvasive properties of the virus as demonstrated in studies, and further verified by neurological illnesses in patients, present a special threat to mankind. Clinicians must be prepared to recognize and treat these neurological complications and start treatment to limit long-lasting brain injury as seen in patients with COVID-19.

Citing Articles

Current Evidence and Practice Guidelines of Systemic Complications of 2022 Mpox Outbreak: A Scoping Review.

Ajmera K, Shah H, Chourasia P, Chitturi S Cureus. 2023; 15(9):e45754.

PMID: 37771934 PMC: 10529470. DOI: 10.7759/cureus.45754.

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