The Additive Effects of Bioactive Glasses and Photobiomodulation on Enhancing Bone Regeneration

Overview

Journal Regen Biomater

Specialty Biomedical Engineering

Date 2023 Apr 6

PMID 37020752

Authors

Lidong Huang

Weiyu Gong

Guibin Huang

Jingyi Li

Jilin Wu

Yanmei Dong

Affiliations

Soon will be listed here.

Abstract

Bioactive glasses (BG) have been generally used in bone defects repair for its good osteoinductivity and osteoconductivity. However, the early angiogenesis of BG in the repair of large-sized bone defects may not be sufficient enough to support new bone formation, resulting in the failure of bone repair. Photobiomodulation (PBM) therapy, which is superior on promoting early angiogenesis, may contribute to the angiogenesis of BG and further enhance the repair of bone defects. Therefore, we applied BG and PBM in combination and preliminarily investigated their additive effects on bone regeneration both and . The results revealed that BG combined with PBM remarkably enhanced human bone marrow mesenchymal stem cells proliferation, osteogenic-related genes expression and mineralization, which was better than applying BG or PBM respectively. For studies, the histological staining results showed that BG induced new bone formation in the interior of defects and promoted new bone reconstruction at 6 weeks post-operation. The micro-computed tomography results further confirmed that BG combined with PBM accelerated bone formation and maturation, improved the speed and quality of bone regeneration, and promoted bone repair. In conclusion, with the optimum BG and PBM parameters, BG combined with PBM generated additive effects on promoting bone regeneration.

Citing Articles

Microfluidic 3D cell culture: potential application of collagen hydrogels with an optimal dose of bioactive glasses.

Ghobadi F, Saadatmand M, Simorgh S, Brouki Milan P Sci Rep. 2025; 15(1):569.

PMID: 39747624 PMC: 11696724. DOI: 10.1038/s41598-024-84346-8.

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