Mechanism for Exercise-mediated Prevention Against Muscle Wasting on Extensor Digitorum Longus Muscle in Spontaneously Diabetic Torii Fatty Rats

Overview

Journal J Physiol Sci

Specialty Physiology

Date 2023 Apr 4

PMID 37016292

Authors

Hitoshi Kotake

Yuji Ogura

Shohei Yamada

Kazuho Inoue

Shiika Watanabe

Daisuke Ichikawa

Takeshi Sugaya

Keiichi Ohata

Yasunori Natsuki

Seiko Hoshino

Minoru Watanabe

Kenjiro Kimura

Yugo Shibagaki

Atsuko Kamijo-Ikemori

Affiliations

Soon will be listed here.

Abstract

We previously reported the significant increase in limb muscle strength and cross-sectional area of the type IIb muscle fibers in the extensor digitorum longus (EDL) muscle in a type 2 diabetic animal model, with Spontaneously Diabetic Torii (SDT) fatty rats (n = 6) undergoing regular treadmill exercise from 8 to 16 weeks of age compared with sedentary SDT fatty rats (n = 6). This study investigated the mechanism by which exercise training prevented skeletal muscle wasting in the EDL muscle of the SDT fatty rats. The endurance exercise for 8 weeks downregulated the expression of muscle RING-finger protein-1 (an E3 ubiquitin ligase) and upregulated the expression of CD31, insulin receptor substrate-2, and phosphorylated endothelial nitric oxide synthase in the EDL muscle of 16-week-old SDT fatty rats.Endurance exercise training might reduce muscle wasting by preventing muscle degradation and increasing the angiogenic response in the EDL muscle in type 2 diabetes.

Citing Articles

MCC950 Ameliorates Diabetic Muscle Atrophy in Mice by Inhibition of Pyroptosis and Its Synergistic Effect with Aerobic Exercise.

Yan X, Fu P, Zhang Y, Ling D, Reynolds L, Hua W Molecules. 2024; 29(3).

PMID: 38338456 PMC: 10856337. DOI: 10.3390/molecules29030712.

References

Leger B, Cartoni R, Praz M, Lamon S, Deriaz O, Crettenand A . Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy. J Physiol. 2006; 576(Pt 3):923-33. PMC: 1890416. DOI: 10.1113/jphysiol.2006.116715. View

Bolster D, Crozier S, Kimball S, Jefferson L . AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem. 2002; 277(27):23977-80. DOI: 10.1074/jbc.C200171200. View

Pfeifer L, De Nardi A, Xavier Neves da Silva L, Botton C, do Nascimento D, Teodoro J . Association Between Physical Exercise Interventions Participation and Functional Capacity in Individuals with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Controlled Trials. Sports Med Open. 2022; 8(1):34. PMC: 8897547. DOI: 10.1186/s40798-022-00422-1. View

Shono N, Urata H, Saltin B, Mizuno M, Harada T, Shindo M . Effects of low intensity aerobic training on skeletal muscle capillary and blood lipoprotein profiles. J Atheroscler Thromb. 2002; 9(1):78-85. DOI: 10.5551/jat.9.78. View

Fiuza-Luces C, Santos-Lozano A, Joyner M, Carrera-Bastos P, Picazo O, Zugaza J . Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors. Nat Rev Cardiol. 2018; 15(12):731-743. DOI: 10.1038/s41569-018-0065-1. View

Rasmussen B, Hancock C, Winder W . Postexercise recovery of skeletal muscle malonyl-CoA, acetyl-CoA carboxylase, and AMP-activated protein kinase. J Appl Physiol (1985). 1998; 85(5):1629-34. DOI: 10.1152/jappl.1998.85.5.1629. View

Moriscot A, Baptista I, Bogomolovas J, Witt C, Hirner S, Granzier H . MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance. J Struct Biol. 2010; 170(2):344-53. PMC: 2856802. DOI: 10.1016/j.jsb.2010.02.001. View

Tanabe J, Ogura Y, Kosaki K, Nagai Y, Sugaya T, Ohata K . Relationship between Urinary Liver-Type Fatty Acid-Binding Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats. J Diabetes Res. 2020; 2020:7614035. PMC: 7201485. DOI: 10.1155/2020/7614035. View

Zhang X, Zhao Y, Chen S, Shao H . Anti-diabetic drugs and sarcopenia: emerging links, mechanistic insights, and clinical implications. J Cachexia Sarcopenia Muscle. 2021; 12(6):1368-1379. PMC: 8718027. DOI: 10.1002/jcsm.12838. View

10.

Kotake H, Yamada S, Ogura Y, Watanabe S, Inoue K, Ichikawa D . Endurance Exercise Training-Attenuated Diabetic Kidney Disease with Muscle Weakness in Spontaneously Diabetic Torii Fatty Rats. Kidney Blood Press Res. 2021; 47(3):203-218. DOI: 10.1159/000521464. View

11.

Cai D, Frantz J, Tawa Jr N, Melendez P, Oh B, Lidov H . IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell. 2004; 119(2):285-98. DOI: 10.1016/j.cell.2004.09.027. View

12.

Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M . Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature. 2010; 464(7293):1313-9. DOI: 10.1038/nature08991. View

13.

Schiaffino S, Mammucari C . Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models. Skelet Muscle. 2011; 1(1):4. PMC: 3143906. DOI: 10.1186/2044-5040-1-4. View

14.

Ato S, Kido K, Sato K, Fujita S . Type 2 diabetes causes skeletal muscle atrophy but does not impair resistance training-mediated myonuclear accretion and muscle mass gain in rats. Exp Physiol. 2019; 104(10):1518-1531. PMC: 6790689. DOI: 10.1113/EP087585. View

15.

Nindl B, Pierce J . Insulin-like growth factor I as a biomarker of health, fitness, and training status. Med Sci Sports Exerc. 2009; 42(1):39-49. DOI: 10.1249/MSS.0b013e3181b07c4d. View

16.

Chen G, Mou C, Yang Y, Wang S, Zhao Z . Exercise training has beneficial anti-atrophy effects by inhibiting oxidative stress-induced MuRF1 upregulation in rats with diabetes. Life Sci. 2011; 89(1-2):44-9. DOI: 10.1016/j.lfs.2011.04.018. View

17.

Dehoux M, Van Beneden R, Pasko N, Lause P, Verniers J, Underwood L . Role of the insulin-like growth factor I decline in the induction of atrogin-1/MAFbx during fasting and diabetes. Endocrinology. 2004; 145(11):4806-12. DOI: 10.1210/en.2004-0406. View

18.

Nakashima K, Ishida A . AMP-activated Protein Kinase Activation Suppresses Protein Synthesis and mTORC1 Signaling in Chick Myotube Cultures. J Poult Sci. 2022; 59(1):81-85. PMC: 8791771. DOI: 10.2141/jpsa.0210021. View

19.

Yamada S, Ogura Y, Inoue K, Tanabe J, Sugaya T, Ohata K . Effect of GLP-1 receptor agonist, liraglutide, on muscle in spontaneously diabetic torii fatty rats. Mol Cell Endocrinol. 2021; 539:111472. DOI: 10.1016/j.mce.2021.111472. View

20.

Noh K, Chung K, Choi Y, Park M, Jang E, Park C . β-Hydroxy β-methylbutyrate improves dexamethasone-induced muscle atrophy by modulating the muscle degradation pathway in SD rat. PLoS One. 2014; 9(7):e102947. PMC: 4102592. DOI: 10.1371/journal.pone.0102947. View