F-FDG PET/CT Imaging of Posttransplant Lymphoproliferative Disorder Following Renal Transplantation: Three Clinical Cases

Overview

Journal Heliyon

Specialty Social Sciences

Date 2023 Apr 4

PMID 37012908

Authors

Bo Pan

Xingxing Zhu

Affiliations

Soon will be listed here.

Abstract

Posttransplant lymphoproliferative disorder (PTLD) is a serious complication of kidney transplantation, and whole-body F- FDG PET/CT imaging plays a key role in patients with PTLD. This article reports three cases of F-FDG PET/CT manifestations of gastric, prostate, and pulmonary lymphomas after kidney transplantation, all of which showed local lesions without involvement of adjacent or distant lymph nodes and lymphoid node organs. All patients were treated with a reduced dose of R-CHOP and were generally in a good condition after discharge. Early diagnosis and reasonable treatment are key factors in achieving a better prognosis in patients with PTLD, and whole-body F-FDG PET/CT imaging plays an important role in the diagnosis and monitoring of PTLD.

Citing Articles

A New Era for PET/CT: Applications in Non-Tumorous Renal Pathologies.

Moghrabi S, Abdlkadir A, Al-Hajaj N, Gnanasegaran G, Kumar R, Syed G J Clin Med. 2024; 13(16).

PMID: 39200774 PMC: 11355182. DOI: 10.3390/jcm13164632.

References

Ballova V, Muoio B, Albano D, Bertagna F, Canziani L, Ghielmini M . Diagnostic Performance of F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-Analysis. Diagnostics (Basel). 2020; 10(2). PMC: 7168294. DOI: 10.3390/diagnostics10020101. View

Colleoni G, Oliveira J, Borducchi D, Fernandes M, Da Silva H, Alves A . Post-transplant lymphoproliferative disorders (PTLD) after renal transplantation: management and evolution of seven cases among 1002 renal transplants in São Paulo, Brazil. Leuk Lymphoma. 2000; 39(1-2):145-50. DOI: 10.3109/10428190009053548. View

Liu L, Liu Q, Feng S . Management of Epstein-Barr virus-related post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation. Ther Adv Hematol. 2020; 11:2040620720910964. PMC: 7236397. DOI: 10.1177/2040620720910964. View

Hyun H, Park E, Cho M, Min S, Ha J, Kang H . Post-Transplant Lymphoproliferative Diseases in Pediatric Kidney Allograft Recipients with Epstein-Barr Virus Viremia. J Korean Med Sci. 2019; 34(30):e203. PMC: 6676002. DOI: 10.3346/jkms.2019.34.e203. View

Ready E, Chernushkin K, Partovi N, Hussaini T, Luo C, Johnston O . Posttransplant Lymphoproliferative Disorder in Adults Receiving Kidney Transplantation in British Columbia: A Retrospective Cohort Analysis. Can J Kidney Health Dis. 2018; 5:2054358118760831. PMC: 5888818. DOI: 10.1177/2054358118760831. View

Francis A, Johnson D, Teixeira-Pinto A, Craig J, Wong G . Incidence and predictors of post-transplant lymphoproliferative disease after kidney transplantation during adulthood and childhood: a registry study. Nephrol Dial Transplant. 2018; 33(5):881-889. DOI: 10.1093/ndt/gfx356. View

Tsai D, Douglas L, Andreadis C, Vogl D, Arnoldi S, Kotloff R . EBV PCR in the diagnosis and monitoring of posttransplant lymphoproliferative disorder: results of a two-arm prospective trial. Am J Transplant. 2008; 8(5):1016-24. DOI: 10.1111/j.1600-6143.2008.02183.x. View

Wang Z, Xu Y, Zhao J, Fu Y . Epstein-Barr virus-associated monomorphic post-transplant lymphoproliferative disorder after pediatric kidney transplantation: A case report. World J Clin Cases. 2021; 9(2):469-475. PMC: 7812878. DOI: 10.12998/wjcc.v9.i2.469. View

Newstead C . Lymphoproliferative disease post-renal transplantation. Nephrol Dial Transplant. 2000; 15(12):1913-6. DOI: 10.1093/ndt/15.12.1913. View

10.

Abbas F, Kossi M, Shaheen I, Sharma A, Halawa A . Post-transplantation lymphoproliferative disorders: Current concepts and future therapeutic approaches. World J Transplant. 2020; 10(2):29-46. PMC: 7093305. DOI: 10.5500/wjt.v10.i2.29. View

11.

Agarwal G, Mannon R . Post-Transplant Lymphoproliferative Disorder in a Kidney Transplant Recipient. Clin J Am Soc Nephrol. 2019; 14(5):751-753. PMC: 6500951. DOI: 10.2215/CJN.00180119. View

12.

Gwon J, Kim Y, Han D . Different causes of early and late-onset post transplant lymphoproliferative disorder in kidney transplantation patients after 2000. Asian J Surg. 2018; 42(4):551-556. DOI: 10.1016/j.asjsur.2018.09.002. View

13.

Montes de Jesus F, Vergote V, Noordzij W, Dierickx D, Dierckx R, Diepstra A . Semi-Quantitative Characterization of Post-Transplant Lymphoproliferative Disorder Morphological Subtypes with [F]FDG PET/CT. J Clin Med. 2021; 10(2). PMC: 7835947. DOI: 10.3390/jcm10020361. View

14.

Metser U, Lo G . FDG-PET/CT in abdominal post-transplant lymphoproliferative disease. Br J Radiol. 2015; 89(1057):20150844. PMC: 4985967. DOI: 10.1259/bjr.20150844. View

15.

Montes de Jesus F, Kwee T, Kahle X, Nijland M, van Meerten T, Huls G . Diagnostic performance of FDG-PET/CT of post-transplant lymphoproliferative disorder and factors affecting diagnostic yield. Eur J Nucl Med Mol Imaging. 2019; 47(3):529-536. PMC: 7005092. DOI: 10.1007/s00259-019-04481-7. View

16.

Seo E, Kim J, Oh S, Kim K, Kim D, Lee J . Epstein-Barr viral load monitoring for diagnosing post-transplant lymphoproliferative disorder in pediatric liver transplant recipients. Pediatr Transplant. 2020; 24(4):e13666. DOI: 10.1111/petr.13666. View

17.

Grenda R . Non-Hodgkin lymphoma after pediatric kidney transplantation. Pediatr Nephrol. 2021; 37(8):1759-1773. PMC: 9239945. DOI: 10.1007/s00467-021-05205-6. View

18.

Abdulovski R, Moller D, Knudsen A, Sorensen S, Rasmussen A, Nielsen S . Early- and late-onset posttransplant lymphoproliferative disorders among adult kidney and liver transplant recipients. Eur J Haematol. 2022; 109(4):343-350. PMC: 9543731. DOI: 10.1111/ejh.13815. View