Backtracking Cryptic Recurrence of Esophageal Cancer from Membranous Nephropathy: the Detection of Glomerular NELL-1 and IgG4

Overview

Journal Clin Kidney J

Publisher Oxford University Press

Specialty Nephrology

Date 2023 Apr 3

PMID 37007702

Authors

Shuai Zhou

FuLei Meng

ShuLing Yue

Hang Li

Lihong Zhang

Tao Wang

Affiliations

Soon will be listed here.

Abstract

We reported the detection of neural epidermal growth factor-like 1 (NELL-1) and immunoglobulin G4 (IgG4) on glomerular capillary wall in membrane nephropathy (MN), which led to the discovery of early post-operative recurrence of esophageal squamous cell cancer (ESCC) in a 68-year-old man. Further, NELL-1 was also identified in the cancerous tissue sampled by esophagoscope. Moreover, serum IgG4 percentage seemed to be higher when comparing with both previous reports and another age-matched male with NELL-1-negative MN upon fully recovered ESCC. Therefore, the finding of NELL-1 in a renal biopsy should trigger a detailed workup in search of malignancy, especially with concomitant IgG4 dominance.

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