Adjuvants in the Induction of Suppressor Cells

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1979 Feb 1

PMID 370015

Citations 7

Authors

R Neta

S B SALVIN

Affiliations

Soon will be listed here.

Abstract

The effect of different mycobacterial adjuvants on the parameters of delayed hypersensitivity was investigated in strain 13 guinea pigs. The composition of the tubercle bacilli and the type of vehicle in which the antigen was presented determined the presence and extent of suppressor cell activity. When antigen was introduced in complete Freund adjuvant, both adherent and nonadherent cells had suppressive properties, with the suppressive effect demonstrable in vitro from 1 to 5 weeks after sensitization. Suppressor activity was indicated in vivo by a reduction of delayed footpad hypersensitivity in animals presensitized with complete Freund adjuvant.

Citing Articles

A rapid passive hemagglutination method for demonstrating serum antibodies to Candida albicans.

Royal Jr G, SAMPSON C, Faggett T J Natl Med Assoc. 1981; 73(12):1135-8.

PMID: 7328688 PMC: 2552773.

Effect of route of Mycobacterium bovis BCG administration on induction of suppression of sporozoite immunity in rodent malaria.

Smrkovski L Infect Immun. 1981; 31(1):408-12.

PMID: 7012001 PMC: 351798. DOI: 10.1128/iai.31.1.408-412.1981.

Suppressor cell regulation of cell-mediated immune responses in renal infection in vitro modulation of suppressor cell activity.

Miller T, Marshall E J Clin Invest. 1980; 66(4):621-8.

PMID: 6448267 PMC: 371634. DOI: 10.1172/JCI109897.

Induction of delayed type hypersensitivity against ultrasonicated Mycobacterium lepraemurium bacilli without simultaneous local reactivity against live bacilli or protective immunity.

Lovik M, Closs O Clin Exp Immunol. 1983; 53(2):319-27.

PMID: 6349877 PMC: 1535682.

Mechanisms in the in vivo release of lymphokines: relationship of high and low responsiveness to other parameters of the immune response.

Neta R, SALVIN S Infect Immun. 1981; 34(1):160-5.

PMID: 6170585 PMC: 350837. DOI: 10.1128/iai.34.1.160-165.1981.

References

Mackaness G . THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE. J Exp Med. 1964; 120:105-20. PMC: 2137723. DOI: 10.1084/jem.120.1.105. View

JANKOVIC B . Impairment of immunological reactivity in guinea pigs by prior injection of adjuvant. Nature. 1962; 193:789-90. DOI: 10.1038/193789a0. View

Neta R, SALVIN S . T and B lymphocytes in the regulation of delayed hypersensitivity. J Immunol. 1976; 117(5 Pt.2):2014-20. View

Neta R, Winkelstein A, SALVIN S, MENDELOW H . The effect of cyclophosphamide on suppressor cells in guinea pigs. Cell Immunol. 1977; 33(2):402-11. DOI: 10.1016/0008-8749(77)90168-x. View

Ha T, Waksman B . Role of the thymus in tolerance. X. "Suppressor" activity of antigen-stimulated rat thymocytes transferred to normal recipients. J Immunol. 1973; 110(5):1290-9. View

Allwood G, Asherson G . Depression of delayed hypersensitivity by pretreatment with Freund-type adjuvants. II. Mechanism of the phenomenon. Clin Exp Immunol. 1971; 9(2):259-66. PMC: 1713028. View

FELDMAN J . Immunological enhancement: a study of blocking antibodies. Adv Immunol. 1972; 15:167-214. DOI: 10.1016/s0065-2776(08)60685-9. View

Baker P, STASHAK P, Amsbaugh D, PRESCOTT B . Regulation of the antibody response to type 3 pneumococcal polysaccharide. II. Mode of action of thymic-derived suppressor cells. J Immunol. 1974; 112(1):404-9. View

Swierkosz J, Swanborg R . Suppressor cell control of unresponsiveness to experimental allergic encephalomyelitis. J Immunol. 1975; 115(3):631-3. View

10.

Neta R, SALVIN S . Specific suppression of delayed hypersensitivity: the possible presence of a suppressor B cell in the regulation of delayed hypersensitivity. J Immunol. 1974; 113(6):1716-25. View

11.

GERSHON R . T cell control of antibody production. Contemp Top Immunobiol. 1974; 3:1-40. DOI: 10.1007/978-1-4684-3045-5_1. View

12.

SALVIN S, Neta R . A possible relationship between delayed hypersensitivity and cell-mediated immunity. Am Rev Respir Dis. 1975; 111(4):373-7. DOI: 10.1164/arrd.1975.111.4.373. View

13.

Neta R, SALVIN S . Specific depression of delayed hypersensitivity to purified proteins, with relation to production of circulating antibody. Cell Immunol. 1973; 9(2):242-50. DOI: 10.1016/0008-8749(73)90075-0. View

14.

SALVIN S, Nishio J . Communications. "In vitro" cell reactions in delayed hypersensitivity. J Immunol. 1969; 103(1):138-41. View

15.

SALVIN S, Ribi E, Granger D, Youngner J . Migration inhibitory factor and type II interferon in the circulation of mice sensitized with mycobacterial components. J Immunol. 1975; 114(1 Pt 2):354-9. View

16.

Fujimoto S, Greene M, Sehon A . Regualtion of the immune response to tumor antigens. I. Immunosuppressor cells in tumor-bearing hosts. J Immunol. 1976; 116(3):791-9. View

17.

Reinisch C, Gleiner N, Schlossman S . Adjuvant regulation of T cell function. J Immunol. 1976; 116(3):710-5. View

18.

Veit B, FELDMAN J . Altered lymphocyte functions in rats bearing syngeneic Moloney sarcoma tumors. II. Suppressor cells. J Immunol. 1976; 117(2):655-60. View