Multiple Sclerosis: Neuroimmune Crosstalk and Therapeutic Targeting

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2023 Mar 31

PMID 37001498

Authors

Marc Charabati

Michael A Wheeler

Howard L Weiner

Francisco J Quintana

Affiliations

Soon will be listed here.

Abstract

Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system afflicting nearly three million individuals worldwide. Neuroimmune interactions between glial, neural, and immune cells play important roles in MS pathology and offer potential targets for therapeutic intervention. Here, we review underlying risk factors, mechanisms of MS pathogenesis, available disease modifying therapies, and examine the value of emerging technologies, which may address unmet clinical needs and identify novel therapeutic targets.

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