Association Between Transforming Growth Factor-β1 Polymorphisms and Ischemic Stroke Susceptibility: A Meta-Analysis

Overview

Journal Clin Appl Thromb Hemost

Publisher Sage Publications

Specialty Cardiology & Vascular Diseases

Date 2023 Mar 31

PMID 36998191

Authors

Xiao-Qin Peng

Fan Cheng

Lan Zhou

Affiliations

Soon will be listed here.

Abstract

Epidemiological studies have suggested a potential relationship between the transforming growth factor-β1 (TGF-β1) gene and ischemic stroke (IS) risk; however, the current results are inconsistent. Therefore, we performed this meta-analysis to assess the precise association between TGF-β1 polymorphisms and IS risk. Online databases were searched for themes related to TGF-β1 polymorphisms and ARE risk. Quantitative calculations of odds ratios (ORs) and confidence intervals (CIs) were performed using 5 genetic models of each variant locus. Heterogeneity tests, cumulative analyses, sensitivity analyses, and publication bias were conducted to examine statistical power. Moreover, changes in the secondary structure and minimum free energy (MFE) were explored using in silico analysis. Nineteen case-control studies were included in our meta-analysis on rs1800468 G>A, rs1800469 C>T, and rs1800470 T>C polymorphisms and IS risk. Overall, only a marginal association was found between the rs1800469 C>T polymorphism and IS risk (T vs C: OR = 1.12, 95%CI = 1.00-1.46, P = .05, I = 77.0%). Otherwise, no significant association was observed between the rs1800468 G>A and rs1800470 T>C polymorphisms and IS risk in general and stratified analyses. Moreover, no significant changes in secondary structure and MFE were found in any of the 3 polymorphic loci. Current evidence cautiously suggests that TGF-β1 polymorphisms are not associated with IS susceptibility.

References

Salmeron K, Maniskas M, Edwards D, Wong R, Rajkovic I, Trout A . Interleukin 1 alpha administration is neuroprotective and neuro-restorative following experimental ischemic stroke. J Neuroinflammation. 2019; 16(1):222. PMC: 6857151. DOI: 10.1186/s12974-019-1599-9. View

Chiang H, Chu P, Chen S, Lee T . MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF-β1 signaling. Commun Biol. 2022; 5(1):364. PMC: 9018696. DOI: 10.1038/s42003-022-03313-z. View

Yao T, Li J, Long Q, Li G, Ding Y, Cui Q . Association between Serum Gamma-glutamyl transferase and Intracranial Arterial Calcification in Acute Ischemic Stroke Subjects. Sci Rep. 2019; 9(1):19998. PMC: 6934471. DOI: 10.1038/s41598-019-56569-7. View

Peng Z, Zhan L, Chen S, Xu E . Association of transforming growth factor-β1 gene C-509T and T869C polymorphisms with atherosclerotic cerebral infarction in the Chinese: a case-control study. Lipids Health Dis. 2011; 10:100. PMC: 3129580. DOI: 10.1186/1476-511X-10-100. View

Zhang L, Wei W, Ai X, Kilic E, Hermann D, Venkataramani V . Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway. Cell Death Dis. 2021; 12(11):1068. PMC: 8578653. DOI: 10.1038/s41419-021-04363-7. View

Seong D, Yi S, Han S, Lee J, Park S, Hwang Y . Target ischemic stroke model creation method using photoacoustic microscopy with simultaneous vessel monitoring and dynamic photothrombosis induction. Photoacoustics. 2022; 27:100376. PMC: 9207728. DOI: 10.1016/j.pacs.2022.100376. View

Ding Q, Liu S, Yao Y, Liu H, Cai T, Han L . Global, Regional, and National Burden of Ischemic Stroke, 1990-2019. Neurology. 2021; 98(3):e279-e290. DOI: 10.1212/WNL.0000000000013115. View

Donkor E . Stroke in the 21 Century: A Snapshot of the Burden, Epidemiology, and Quality of Life. Stroke Res Treat. 2019; 2018:3238165. PMC: 6288566. DOI: 10.1155/2018/3238165. View

Kumar P, Misra S, Kumar A, Faruq M, Shakya S, Vardhan G . Transforming growth factor-β1 (C509T, G800A, and T869C) gene polymorphisms and risk of ischemic stroke in North Indian population: A hospital-based case-control study. Ann Indian Acad Neurol. 2017; 20(1):5-12. PMC: 5341267. DOI: 10.4103/0972-2327.199910. View

10.

Kumar P, Kumar A, Srivastava M, Misra S, Pandit A, Prasad K . Association of Transforming Growth Factor Beta-1-509C/T Gene Polymorphism with Ischemic Stroke: A Meta Analysis. Basic Clin Neurosci. 2016; 7(2):91-6. PMC: 4892324. DOI: 10.15412/J.BCN.03070202. View

11.

Saini V, Guada L, Yavagal D . Global Epidemiology of Stroke and Access to Acute Ischemic Stroke Interventions. Neurology. 2021; 97(20 Suppl 2):S6-S16. DOI: 10.1212/WNL.0000000000012781. View

12.

Bobik A . Transforming growth factor-betas and vascular disorders. Arterioscler Thromb Vasc Biol. 2006; 26(8):1712-20. DOI: 10.1161/01.ATV.0000225287.20034.2c. View

13.

Bamford J, Sandercock P, Dennis M, Burn J, Warlow C . Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet. 1991; 337(8756):1521-6. DOI: 10.1016/0140-6736(91)93206-o. View

14.

Wang M, Jiang L, Monticone R, Lakatta E . Proinflammation: the key to arterial aging. Trends Endocrinol Metab. 2013; 25(2):72-9. PMC: 3917314. DOI: 10.1016/j.tem.2013.10.002. View

15.

Kim Y, Lee C . The gene encoding transforming growth factor beta 1 confers risk of ischemic stroke and vascular dementia. Stroke. 2006; 37(11):2843-5. DOI: 10.1161/01.STR.0000244782.76917.87. View

16.

Hecht E, Freise C, Websky K, Nasser H, Kretzschmar N, Stawowy P . The matrix metalloproteinases 2 and 9 initiate uraemic vascular calcifications. Nephrol Dial Transplant. 2015; 31(5):789-97. DOI: 10.1093/ndt/gfv321. View

17.

Sie M, Uitterlinden A, Bos M, Arp P, Breteler M, Koudstaal P . TGF-beta 1 polymorphisms and risk of myocardial infarction and stroke: the Rotterdam Study. Stroke. 2006; 37(11):2667-71. DOI: 10.1161/01.STR.0000244779.30070.1a. View

18.

Zhou M, Wang H, Zeng X, Yin P, Zhu J, Chen W . Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2019; 394(10204):1145-1158. PMC: 6891889. DOI: 10.1016/S0140-6736(19)30427-1. View

19.

Grainger D . Transforming growth factor beta and atherosclerosis: so far, so good for the protective cytokine hypothesis. Arterioscler Thromb Vasc Biol. 2003; 24(3):399-404. DOI: 10.1161/01.ATV.0000114567.76772.33. View

20.

Gao P, Wu W, Ye J, Lu Y, Adam A, Singer H . Transforming growth factor β1 suppresses proinflammatory gene program independent of its regulation on vascular smooth muscle differentiation and autophagy. Cell Signal. 2018; 50:160-170. PMC: 6389266. DOI: 10.1016/j.cellsig.2018.07.002. View