Predictive Value of Immune Cells in the Risk of Gestational Diabetes Mellitus: A Pilot Study

Overview

Journal Front Clin Diabetes Healthc

Specialty Endocrinology

Date 2023 Mar 30

PMID 36992781

Authors

Adnette Fagninou

Magloire Pandoua Nekoua

Salomon Ezechiel M Fiogbe

Kabirou Moutairou

Akadiri Yessoufou

Affiliations

Soon will be listed here.

Abstract

Aims: Immunological and biochemical parameters are gaining more and more importance in the prognosis of diabetes and its complications. Here, we assessed the predictive power of immune cells correlated with biochemical parameters in gestational diabetes mellitus (GDM).

Materials And Methods: Immune cells and serum biochemical parameters were determined in women with GDM and pregnant controls. Receiver operating characteristics (ROC) curve analyses were conducted to assess the optimal cutoff and value of ratios of immune cells to biochemical parameters for predicting GDM.

Results: Blood glucose, total cholesterol, LDL-cholesterol and triglycerides were significantly increased whereas HDL-cholesterol decreased in women with GDM compared to pregnant controls. Glycated hemoglobin, creatinine, transaminase activities did not significantly differ between both groups. Total leukocyte, lymphocyte and platelet numbers were significantly high in women with GDM. Correlation tests showed that ratios of lymphocyte/HDL-C, monocyte/HDL-C and granulocyte/HDL-C were significantly higher in women with GDM than in pregnant controls ( = 0.001; = 0.009 and = 0.004 respectively). Women with a lymphocyte/HDL-C ratio greater than 3.66 had a 4-fold increased risk of developing GDM than those with lower ratios (odds ratio 4.00; 95% CI: 1.094 - 14.630; =0.041).

Conclusion: Our study showed that ratios of lymphocyte, monocyte and granulocyte to HDL-C might represent valuable biomarkers for GDM and in particular, lymphocyte/HDL-C ratio exhibited a strong predictive power for GDM risk.

Citing Articles

A new marker predicting gestational diabetes mellitus: First trimester neutrophil/lymphocyte ratio.

Sahin M, Oguz A, Tuzun D, Isiktas O, Isiktas S, Ulgen C Medicine (Baltimore). 2022; 101(36):e30514.

PMID: 36086702 PMC: 10980480. DOI: 10.1097/MD.0000000000030511.

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