Hemagglutinin Antibodies in the Polish Population During the 2019/2020 Epidemic Season

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2023 Mar 30

PMID 36992469

Authors

Karol Szymanski

Katarzyna Kondratiuk

Ewelina Hallmann

Anna Poznanska

Lidia B Brydak

Affiliations

Soon will be listed here.

Abstract

The aim of the study was to determine the level of antibodies against hemagglutinin of influenza viruses in the serum of subjects belonging to seven different age groups in the 2019/2020 epidemic season. The level of anti-hemagglutinin antibodies was tested using the hemagglutination inhibition (HAI) test. The tests included 700 sera from all over Poland. Their results confirmed the presence of antibodies against the following influenza virus antigens: A/Brisbane/02/2018 (H1N1)pdm09 (48% of samples), A/Kansas/14/2017/ (H3N2) (74% of samples), B/Colorado/06/ 2017 Victoria line (26% of samples), and B/Phuket/3073/2013 Yamagata line (63% of samples). The level of antibodies against hemagglutinin varied between the age groups. The highest average (geometric mean) antibody titer (68.0) and the highest response rate (62%) were found for the strain A/Kansas/14/2017/ (H3N2). During the epidemic season in Poland, only 4.4% of the population was vaccinated.

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References

Wilson G, Ye Z, Xie H, Vahl S, Dawson E, Rowlen K . Automated interpretation of influenza hemagglutination inhibition (HAI) assays: Is plate tilting necessary?. PLoS One. 2017; 12(6):e0179939. PMC: 5491073. DOI: 10.1371/journal.pone.0179939. View

Solomon D, Sherman A, Kanjilal S . Influenza in the COVID-19 Era. JAMA. 2020; 324(13):1342-1343. DOI: 10.1001/jama.2020.14661. View

Ghebrehewet S, MacPherson P, Ho A . Influenza. BMJ. 2016; 355:i6258. PMC: 5141587. DOI: 10.1136/bmj.i6258. View

Kowalczyk D, Szymanski K, Cieslak K, Brydak L . Circulation of Antibodies Against Influenza Virus Hemagglutinins in the 2014/2015 Epidemic Season in Poland. Adv Exp Med Biol. 2017; 968:35-40. DOI: 10.1007/5584_2016_191. View

Bouvier N, Palese P . The biology of influenza viruses. Vaccine. 2009; 26 Suppl 4:D49-53. PMC: 3074182. DOI: 10.1016/j.vaccine.2008.07.039. View

Chotpitayasunondh T, Fischer T, Heraud J, Hurt A, Monto A, Osterhaus A . Influenza and COVID-19: What does co-existence mean?. Influenza Other Respir Viruses. 2020; 15(3):407-412. PMC: 8051702. DOI: 10.1111/irv.12824. View

Paules C, Subbarao K . Influenza. Lancet. 2017; 390(10095):697-708. DOI: 10.1016/S0140-6736(17)30129-0. View

Gaitonde D, Moore F, Morgan M . Influenza: Diagnosis and Treatment. Am Fam Physician. 2019; 100(12):751-758. View

Wang Y, Tang C, Wan X . Antigenic characterization of influenza and SARS-CoV-2 viruses. Anal Bioanal Chem. 2021; 414(9):2841-2881. PMC: 8669429. DOI: 10.1007/s00216-021-03806-6. View

10.

Smetana J, Chlibek R, Shaw J, Splino M, Prymula R . Influenza vaccination in the elderly. Hum Vaccin Immunother. 2017; 14(3):540-549. PMC: 5861798. DOI: 10.1080/21645515.2017.1343226. View

11.

Keilman L . Seasonal Influenza (Flu). Nurs Clin North Am. 2019; 54(2):227-243. DOI: 10.1016/j.cnur.2019.02.009. View

12.

Buchy P, Badur S . Who and when to vaccinate against influenza. Int J Infect Dis. 2020; 93:375-387. DOI: 10.1016/j.ijid.2020.02.040. View

13.

Webster R, Govorkova E . Continuing challenges in influenza. Ann N Y Acad Sci. 2014; 1323:115-39. PMC: 4159436. DOI: 10.1111/nyas.12462. View

14.

Kumar V . Influenza in Children. Indian J Pediatr. 2016; 84(2):139-143. DOI: 10.1007/s12098-016-2232-x. View

15.

Rota P, Wallis T, Harmon M, Rota J, Kendal A, Nerome K . Cocirculation of two distinct evolutionary lineages of influenza type B virus since 1983. Virology. 1990; 175(1):59-68. DOI: 10.1016/0042-6822(90)90186-u. View

16.

Rzepka A, Mania A . The clinical picture of influenza against other respiratory tract infections in a general practitioner practice. Przegl Epidemiol. 2021; 75(2):159-174. DOI: 10.32394/pe.75.15. View

17.

Bednarska K, Nowak M, Kondratiuk K, Hallmann-Szelinska E, Brydak L . Incidence of Circulating Antibodies Against Hemagglutinin of Influenza Viruses in the Epidemic Season 2013/2014 in Poland. Adv Exp Med Biol. 2015; 857:45-50. PMC: 7119922. DOI: 10.1007/5584_2015_118. View

18.

Kim H, Webster R, Webby R . Influenza Virus: Dealing with a Drifting and Shifting Pathogen. Viral Immunol. 2018; 31(2):174-183. DOI: 10.1089/vim.2017.0141. View

19.

Krammer F . The human antibody response to influenza A virus infection and vaccination. Nat Rev Immunol. 2019; 19(6):383-397. DOI: 10.1038/s41577-019-0143-6. View

20.

Reber A, Katz J . Immunological assessment of influenza vaccines and immune correlates of protection. Expert Rev Vaccines. 2013; 12(5):519-36. PMC: 9002926. DOI: 10.1586/erv.13.35. View