Insights into the Molecular Epidemiology of Foot-and-Mouth Disease Virus in Russia, Kazakhstan, and Mongolia in Terms of O/ME-SA/Ind-2001e Sublineage Expansion

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2023 Mar 30

PMID 36992307

Authors

Viktor Nikiforov

Alexey Shcherbakov

Ilya Chvala

Svetlana Kremenchugskaya

Fedor Korennoy

Tamara Mayorova

Anna Timina

Samat Tyulegenov

Sarsenbay Abdrakhmanov

Maksat Berdikulov

Tserenchimed Sainnokhoi

Delgerzul Gombo-Ochir

Tsagaan Tserenchimed

Larisa Prokhvatilova

Alexander Sprygin

Affiliations

Soon will be listed here.

Abstract

Foot-and-mouth disease (FMD) has long been recognized as a highly contagious, transboundary disease of livestock incurring substantial losses and burdens to animal production and trade across Africa, the Middle East, and Asia. Due to the recent emergence of the O/ME-SA/Ind-2001 lineage globally contributing to the expansion of FMD, molecular epidemiological investigations help in tracing the evolution of foot-and-mouth disease virus (FMDV) across endemic and newly affected regions. In this work, our phylogenetic analysis reveals that the recent FMDV incursions in Russia, Mongolia, and Kazakhstan in 2021-2022 were due to the virus belonging to the O/ME-SA/Ind-2001e sublineage, belonging to the cluster from Cambodian FMDV isolates. The studied isolates varied by 1.0-4.0% at the VP1 nucleotide level. Vaccine matching tests indicated that the vaccination policy in the subregion should be tailored according to the peculiarities of the ongoing epidemiologic situation. The current vaccination should change from such vaccine strains as O Manisa (ME-SA), O no 2102/Zabaikalsky/2010 (O/ME-SA/Mya-98) (r = 0.05-0.28) to strains that most closely antigenically match the dominant lineage O No. 2212/Primorsky/2014 (O O/ME-SA//Mya-98) and O No. 2311/Zabaikalsky/2016 (O ME-SA/Ind-2001) (r = 0.66-1.0).

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References

Knowles N, Wadsworth J, Bachanek-Bankowska K, King D . VP1 sequencing protocol for foot and mouth disease virus molecular epidemiology. Rev Sci Tech. 2017; 35(3):741-755. DOI: 10.20506/rst.35.3.2565. View

Knowles N, Bachanek-Bankowska K, Wadsworth J, Mioulet V, Valdazo-Gonzalez B, Eldaghayes I . Outbreaks of Foot-and-Mouth Disease in Libya and Saudi Arabia During 2013 Due to an Exotic O/ME-SA/Ind-2001 Lineage Virus. Transbound Emerg Dis. 2014; 63(5):e431-5. DOI: 10.1111/tbed.12299. View

Kitching R, Knowles N, Samuel A, Donaldson A . Development of foot-and-mouth disease virus strain characterisation--a review. Trop Anim Health Prod. 1989; 21(3):153-66. DOI: 10.1007/BF02250825. View

Abdul-Hamid N, Hussein N, Wadsworth J, Radford A, Knowles N, King D . Phylogeography of foot-and-mouth disease virus types O and A in Malaysia and surrounding countries. Infect Genet Evol. 2010; 11(2):320-8. DOI: 10.1016/j.meegid.2010.11.003. View

Cao Y, Lu Z, Li D, Fan P, Sun P, Bao H . Evaluation of cross-protection against three topotypes of serotype O foot-and-mouth disease virus in pigs vaccinated with multi-epitope protein vaccine incorporated with poly(I:C). Vet Microbiol. 2013; 168(2-4):294-301. DOI: 10.1016/j.vetmic.2013.11.023. View

G G, B G, A K, Hegde R, Kumar N, Prabhakaran K . Foot and Mouth Disease (FMD) incidence in cattle and buffaloes and its associated farm-level economic costs in endemic India. Prev Vet Med. 2021; 190:105318. DOI: 10.1016/j.prevetmed.2021.105318. View

Bachanek-Bankowska K, Wadsworth J, Gray A, Abouchoaib N, King D, Knowles N . Genome Sequence of Foot-and-Mouth Disease Virus Serotype O Isolated from Morocco in 2015. Genome Announc. 2016; 4(2). PMC: 4841151. DOI: 10.1128/genomeA.01746-15. View

Bolortsetseg S, Enkhtuvshin S, Nyamsuren D, Weisman W, Fine A, Yang A . Serosurveillance for foot-and-mouth disease in Mongolian gazelles (Procapra gutturosa) and livestock on the Eastern Steppe of Mongolia. J Wildl Dis. 2012; 48(1):33-8. DOI: 10.7589/0090-3558-48.1.33. View

Brito B, Perez A, Capozzo A . Accuracy of traditional and novel serology tests for predicting cross-protection in foot-and-mouth disease vaccinated cattle. Vaccine. 2013; 32(4):433-6. DOI: 10.1016/j.vaccine.2013.12.007. View

10.

Jamal S, Khan S, Knowles N, Wadsworth J, Hicks H, Mioulet V . Foot-and-mouth disease viruses of the O/ME-SA/Ind-2001e sublineage in Pakistan. Transbound Emerg Dis. 2021; 68(6):3126-3135. DOI: 10.1111/tbed.14134. View

11.

Martinez M, Hernandez J, Piccone M, Palma E, Domingo E, Knowles N . Two mechanisms of antigenic diversification of foot-and-mouth disease virus. Virology. 1991; 184(2):695-706. DOI: 10.1016/0042-6822(91)90439-i. View

12.

Qiu Y, Abila R, Rodtian P, King D, Knowles N, Ngo L . Emergence of an exotic strain of serotype O foot-and-mouth disease virus O/ME-SA/Ind-2001d in South-East Asia in 2015. Transbound Emerg Dis. 2017; 65(1):e104-e112. DOI: 10.1111/tbed.12687. View

13.

Rweyemamu M . Antigenic variation in foot-and-mouth disease: studies based on the virus neutralization reaction. J Biol Stand. 1984; 12(3):323-37. DOI: 10.1016/s0092-1157(84)80013-x. View

14.

Carrillo C, Tulman E, Delhon G, Lu Z, Carreno A, Vagnozzi A . Comparative genomics of foot-and-mouth disease virus. J Virol. 2005; 79(10):6487-504. PMC: 1091679. DOI: 10.1128/JVI.79.10.6487-6504.2005. View

15.

Samuel A, Knowles N . Foot-and-mouth disease type O viruses exhibit genetically and geographically distinct evolutionary lineages (topotypes). J Gen Virol. 2001; 82(Pt 3):609-621. DOI: 10.1099/0022-1317-82-3-609. View

16.

Ryoo S, Lee H, Lim D, Lee J, Bunnary S, Tum S . Identification of the O/ME-SA/Ind-2001e Sublineage of Foot-and-Mouth Disease Virus in Cambodia. Front Vet Sci. 2021; 8:749966. PMC: 8586198. DOI: 10.3389/fvets.2021.749966. View

17.

Bachanek-Bankowska K, Di Nardo A, Wadsworth J, Mioulet V, Pezzoni G, Grazioli S . Reconstructing the evolutionary history of pandemic foot-and-mouth disease viruses: the impact of recombination within the emerging O/ME-SA/Ind-2001 lineage. Sci Rep. 2018; 8(1):14693. PMC: 6168464. DOI: 10.1038/s41598-018-32693-8. View

18.

de Carvalho Ferreira H, Pauszek S, Ludi A, Huston C, Pacheco J, Le V . An Integrative Analysis of Foot-and-Mouth Disease Virus Carriers in Vietnam Achieved Through Targeted Surveillance and Molecular Epidemiology. Transbound Emerg Dis. 2015; 64(2):547-563. DOI: 10.1111/tbed.12403. View

19.

Valdazo-Gonzalez B, Knowles N, King D . Genome Sequences of Foot-and-Mouth Disease Virus O/ME-SA/Ind-2001 Lineage from Outbreaks in Libya, Saudi Arabia, and Bhutan during 2013. Genome Announc. 2014; 2(2). PMC: 3983297. DOI: 10.1128/genomeA.00242-14. View

20.

Valdazo-Gonzalez B, Polihronova L, Alexandrov T, Normann P, Knowles N, Hammond J . Reconstruction of the transmission history of RNA virus outbreaks using full genome sequences: foot-and-mouth disease virus in Bulgaria in 2011. PLoS One. 2012; 7(11):e49650. PMC: 3511503. DOI: 10.1371/journal.pone.0049650. View