Retinal Vessel Geometry in Patients with Idiopathic Epiretinal Membrane

Overview

Journal Sci Rep

Specialty Science

Date 2023 Mar 29

PMID 36991036

Authors

Eun Kyoung Lee

Hye Jee Kim

Sang-Yoon Lee

Su Jeong Song

Hyeong Gon Yu

Affiliations

Soon will be listed here.

Abstract

We investigated the associations between retinal vascular geometric measurements and idiopathic epiretinal membrane (ERM). Whether changes in retinal vascular geometry are independent of systemic cardiovascular risk factors was also evaluated. This retrospective, cross sectional study included 98 patients with idiopathic ERM, and 99 healthy age-matched controls. Quantitative retinal vascular parameters were measured from digital retinal fundus photographs using a semi-automated computer-assisted program. Multivariate logistic regression analyses were performed to evaluate associations between retinal vascular geometric parameters and the presence of idiopathic ERM after adjusting for systemic cardiovascular risk factors. There was no significant difference in the baseline characteristics of the two groups, except that the ERM group had a higher proportion of females than the control group. In multivariate regression analyses, female sex (odds ratio [OR] 0.402; 95% CI 0.196-0.802; P = 0.011), wider retinal venular caliber (OR 16.852; 95% CI 5.384-58.997; P < 0.001) and decreased total fractal dimension (OR 0.156; 95% CI 0.052-0.440; P = 0.001) were associated with idiopathic ERM. Idiopathic ERM was associated with alterations in global retinal microvascular geometric parameters, wider retinal venules, and less complex vascular branching patterns, independent of cardiovascular risk factors.

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References

Coppe A, Lapucci G, Ripandelli G, Pesci F, Buzzonetti L, Iarossi G . Inner Macular Changes in Fellow Eye of Patients With Unilateral Idiopathic Epiretinal Membrane. Invest Ophthalmol Vis Sci. 2021; 62(10):29. PMC: 8399621. DOI: 10.1167/iovs.62.10.29. View

Kwon H, Park S, Lee J, Byon I . MICROVASCULAR LEAKAGE IS A POOR PROGNOSTIC FACTOR FOR IDIOPATHIC EPIRETINAL MEMBRANE: A Fluorescein Angiography Study. Retina. 2021; 41(12):2515-2522. DOI: 10.1097/IAE.0000000000003223. View

Ng C, Cheung N, Wang J, Islam A, Kawasaki R, Meuer S . Prevalence and risk factors for epiretinal membranes in a multi-ethnic United States population. Ophthalmology. 2010; 118(4):694-9. PMC: 3070851. DOI: 10.1016/j.ophtha.2010.08.009. View

Yagi T, Sakata K, Funatsu H, Hori S . Evaluation of perifoveal capillary blood flow velocity before and after vitreous surgery for epiretinal membrane. Graefes Arch Clin Exp Ophthalmol. 2011; 250(3):459-60. DOI: 10.1007/s00417-011-1618-8. View

Liew G, Wang J, Cheung N, Zhang Y, Hsu W, Lee M . The retinal vasculature as a fractal: methodology, reliability, and relationship to blood pressure. Ophthalmology. 2008; 115(11):1951-6. DOI: 10.1016/j.ophtha.2008.05.029. View

Klein R, Klein B, Wang Q, Moss S . The epidemiology of epiretinal membranes. Trans Am Ophthalmol Soc. 1994; 92:403-25; discussion 425-30. PMC: 1298519. View

Hubbard L, Brothers R, King W, Clegg L, Klein R, Cooper L . Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study. Ophthalmology. 1999; 106(12):2269-80. DOI: 10.1016/s0161-6420(99)90525-0. View

Okawa Y, Maruko I, Kawai M, Hasegawa T, Arakawa H, Iida T . Foveal structure and vasculature in eyes with idiopathic epiretinal membrane. PLoS One. 2019; 14(4):e0214881. PMC: 6445520. DOI: 10.1371/journal.pone.0214881. View

Knudtson M, Lee K, Hubbard L, Wong T, Klein R, Klein B . Revised formulas for summarizing retinal vessel diameters. Curr Eye Res. 2003; 27(3):143-9. DOI: 10.1076/ceyr.27.3.143.16049. View

10.

Miyazaki M, Nakamura H, Kubo M, Kiyohara Y, Iida M, Ishibashi T . Prevalence and risk factors for epiretinal membranes in a Japanese population: the Hisayama study. Graefes Arch Clin Exp Ophthalmol. 2003; 241(8):642-6. DOI: 10.1007/s00417-003-0723-8. View

11.

Hart W, Goldbaum M, Cote B, Kube P, Nelson M . Measurement and classification of retinal vascular tortuosity. Int J Med Inform. 1999; 53(2-3):239-52. DOI: 10.1016/s1386-5056(98)00163-4. View

12.

Dery M, Michaud M, Richard D . Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators. Int J Biochem Cell Biol. 2004; 37(3):535-40. DOI: 10.1016/j.biocel.2004.08.012. View

13.

Bringmann A, Unterlauft J, Barth T, Wiedemann R, Rehak M, Wiedemann P . Müller cells and astrocytes in tractional macular disorders. Prog Retin Eye Res. 2021; 86:100977. DOI: 10.1016/j.preteyeres.2021.100977. View

14.

Shinoda K, Kimura I, Eshita T, Kitamura S, Inoue M, Ishida S . Microcirculation in the macular area of eyes with an idiopathic epiretinal membrane. Graefes Arch Clin Exp Ophthalmol. 2002; 239(12):941-5. DOI: 10.1007/s00417-001-0394-2. View

15.

Yim-Lui Cheung C, Ong Y, Ikram M, Ong S, Li X, Hilal S . Microvascular network alterations in the retina of patients with Alzheimer's disease. Alzheimers Dement. 2014; 10(2):135-42. DOI: 10.1016/j.jalz.2013.06.009. View

16.

Cheung C, Tay W, Mitchell P, Wang J, Hsu W, Lee M . Quantitative and qualitative retinal microvascular characteristics and blood pressure. J Hypertens. 2011; 29(7):1380-91. DOI: 10.1097/HJH.0b013e328347266c. View

17.

Lim J, Spee C, Hinton D . A comparison of hypoxia-inducible factor-α in surgically excised neovascular membranes of patients with diabetes compared with idiopathic epiretinal membranes in nondiabetic patients. Retina. 2010; 30(9):1472-8. PMC: 3690285. DOI: 10.1097/IAE.0b013e3181d6df09. View

18.

Kadonosono K, Itoh N, Nomura E, Ohno S . Capillary blood flow velocity in patients with idiopathic epiretinal membranes. Retina. 1999; 19(6):536-9. DOI: 10.1097/00006982-199911000-00010. View

19.

Kadonosono K, Itoh N, Nomura E, Ohno S . Perifoveal microcirculation in eyes with epiretinal membranes. Br J Ophthalmol. 1999; 83(12):1329-31. PMC: 1722895. DOI: 10.1136/bjo.83.12.1329. View

20.

Kawasaki R, Wang J, Mitchell P, Aung T, Saw S, Wong T . Racial difference in the prevalence of epiretinal membrane between Caucasians and Asians. Br J Ophthalmol. 2008; 92(10):1320-4. DOI: 10.1136/bjo.2008.144626. View