Association of Stressful Life Events with Cognitive Impairment in Patients with Type 2 Diabetes Mellitus

Overview

Journal J Diabetes Investig

Specialty Endocrinology

Date 2023 Mar 29

PMID 36987691

Authors

Lina Wang

Shanshan Dong

Chenxu Zhao

Zhaoyu Gao

Lei Jiang

Rui Zhang

Tingting Shen

Yingying Guo

Huimin Zhou

Shunjiang Xu

Affiliations

Soon will be listed here.

Abstract

Aims/introduction: This study was carried out to investigate the relationship of stressful life events (SLEs) with the risk of cognitive impairment in patients with type 2 diabetes mellitus.

Materials And Methods: A total of 316 patients with type 2 diabetes mellitus aged >45 years were recruited in this study, and data on demographics, medical history, lifestyle characteristics and SLEs were collected. The cognitive status of patients was evaluated with a battery of cognitive function scales. Logistic regression analyses were carried out to evaluate the risk and protective factors for mild cognitive impairment (MCI).

Results: Participants, including 217 type 2 diabetes mellitus patients with MCI and 99 patients without MCI, were enrolled in the current study. Among the SLEs, the death of an offspring or parent (odds ratio [OR] 1.994, 95% confidence interval [CI] 1.017-3.908) was a risk factor for MCI after adjustment for age and education level. In the subgroup of participants aged <60 years, the death of an offspring or parent (OR 2.731, 95% CI 1.119-6.665) and financial difficulty (OR 22.205, 95% CI 4.365-112.966) were risk factors for the development of MCI, whereas high working pressure (OR 0.154, 95% CI 0.048-0.495) and career changes (OR 0.324, 95% CI 0.124-0.847) were protective factors for MCI.

Conclusions: These data suggested that SLEs were associated with cognitive function in patients with type 2 diabetes mellitus. Adverse life events, such as the death of an offspring or parent, were risk factors for cognitive impairment, whereas high work pressure in middle-aged people was a protective factor against cognitive impairment.

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