Apelin Is a Prototype of Novel Drugs for the Treatment of Acute Myocardial Infarction and Adverse Myocardial Remodeling

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2023 Mar 29

PMID 36986889

Authors

Sergey V Popov

Leonid N Maslov

Alexandr V Mukhomedzyanov

Boris K Kurbatov

Alexandr S Gorbunov

Michail Kilin

Viacheslav N Azev

Maria S Khlestkina

Galina Z Sufianova

Affiliations

Soon will be listed here.

Abstract

In-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI) is 5-6%. Consequently, it is necessary to develop fundamentally novel drugs capable of reducing mortality in patients with acute myocardial infarction. Apelins could be the prototype for such drugs. Chronic administration of apelins mitigates adverse myocardial remodeling in animals with myocardial infarction or pressure overload. The cardioprotective effect of apelins is accompanied by blockage of the MPT pore, GSK-3β, and the activation of PI3-kinase, Akt, ERK1/2, NO-synthase, superoxide dismutase, glutathione peroxidase, matrix metalloproteinase, the epidermal growth factor receptor, Src kinase, the mitoK channel, guanylyl cyclase, phospholipase C, protein kinase C, the Na/H exchanger, and the Na/Ca exchanger. The cardioprotective effect of apelins is associated with the inhibition of apoptosis and ferroptosis. Apelins stimulate the autophagy of cardiomyocytes. Synthetic apelin analogues are prospective compounds for the development of novel cardioprotective drugs.

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