Spatial Distribution of Drug-Resistant Infections in Rural Eastern Cape Province of South Africa

Overview

Journal Pathogens

Date 2023 Mar 29

PMID 36986397

Authors

Lindiwe M Faye

Mojisola C Hosu

Sandeep Vasaikar

Anzaan Dippenaar

Selien Oostvogels

Rob M Warren

Teke Apalata

Affiliations

Soon will be listed here.

Abstract

Tuberculosis (TB), an infectious airborne disease caused by (Mtb), is a serious public health threat reported as the leading cause of morbidity and mortality worldwide. South Africa is a high-TB-burden country with TB being the highest infectious disease killer. This study investigated the distribution of Mtb mutations and spoligotypes in rural Eastern Cape Province. The Mtb isolates included were 1157 from DR-TB patients and analysed by LPA followed by spoligotyping of 441 isolates. The distribution of mutations and spoligotypes was done by spatial analysis. The gene had the highest number of mutations. The distribution of and mutations was more prevalent in four healthcare facilities, mutations were more prevalent in three healthcare facilities, and heteroresistant isolates were more prevalent in five healthcare facilities. The Mtb was genetically diverse with Beijing more prevalent and largely distributed. Spatial analysis and mapping of gene mutations and spoligotypes revealed a better picture of distribution.

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