AIEgen-Based Nanomaterials for Bacterial Imaging and Antimicrobial Applications: Recent Advances and Perspectives

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Mar 29

PMID 36985835

Authors

Zipeng Shen

Yinzhen Pan

Dingyuan Yan

Dong Wang

Ben Zhong Tang

Affiliations

Soon will be listed here.

Abstract

Microbial infections have always been a thorny problem. Multi-drug resistant (MDR) bacterial infections rendered the antibiotics commonly used in clinical treatment helpless. Nanomaterials based on aggregation-induced emission luminogens (AIEgens) recently made great progress in the fight against microbial infections. As a family of photosensitive antimicrobial materials, AIEgens enable the fluorescent tracing of microorganisms and the production of reactive oxygen (ROS) and/or heat upon light irradiation for photodynamic and photothermal treatments targeting microorganisms. The novel nanomaterials constructed by combining polymers, antibiotics, metal complexes, peptides, and other materials retain the excellent antimicrobial properties of AIEgens while giving other materials excellent properties, further enhancing the antimicrobial effect of the material. This paper reviews the research progress of AIEgen-based nanomaterials in the field of antimicrobial activity, focusing on the materials' preparation and their related antimicrobial strategies. Finally, it concludes with an outlook on some of the problems and challenges still facing the field.

Citing Articles

Synthesis of Side-Chain Liquid Crystalline Polyacrylates with Bridged Stilbene Mesogens.

Konishi G, Sawatari Y, Iwai R, Tanaka T, Shimomura Y, Tokita M Molecules. 2024; 29(21).

PMID: 39519860 PMC: 11547409. DOI: 10.3390/molecules29215220.

Global Trends in Orthopedic Biofilm Research: A Bibliometric Analysis of 1994-2022.

Hu Z, Yin X, Fan G, Liao X J Multidiscip Healthc. 2024; 17:3057-3069.

PMID: 38974376 PMC: 11227867. DOI: 10.2147/JMDH.S465632.

Emerging Issues and Initial Insights into Bacterial Biofilms: From Orthopedic Infection to Metabolomics.

Mirzaei R, Campoccia D, Ravaioli S, Arciola C Antibiotics (Basel). 2024; 13(2).

PMID: 38391570 PMC: 10885942. DOI: 10.3390/antibiotics13020184.

References

Horcajada P, Serre C, Vallet-Regi M, Sebban M, Taulelle F, Ferey G . Metal-organic frameworks as efficient materials for drug delivery. Angew Chem Int Ed Engl. 2006; 45(36):5974-8. DOI: 10.1002/anie.200601878. View

Nicholson J, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W . Host-gut microbiota metabolic interactions. Science. 2012; 336(6086):1262-7. DOI: 10.1126/science.1223813. View

Chen H, Li S, Wu M, Kenry , Huang Z, Lee C . Membrane-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics for Combating Multidrug-Resistant Bacteria. Angew Chem Int Ed Engl. 2019; 59(2):632-636. DOI: 10.1002/anie.201907343. View

Anderson R, Haverkamp R, Yu P . Investigation of morphological changes to Staphylococcus aureus induced by ovine-derived antimicrobial peptides using TEM and AFM. FEMS Microbiol Lett. 2004; 240(1):105-10. DOI: 10.1016/j.femsle.2004.09.027. View

Xu Q, Li X, Jin Y, Sun L, Ding X, Liang L . Bacterial self-defense antibiotics release from organic-inorganic hybrid multilayer films for long-term anti-adhesion and biofilm inhibition properties. Nanoscale. 2017; 9(48):19245-19254. DOI: 10.1039/c7nr07106j. View

Feng G, Yuan Y, Fang H, Zhang R, Xing B, Zhang G . A light-up probe with aggregation-induced emission characteristics (AIE) for selective imaging, naked-eye detection and photodynamic killing of Gram-positive bacteria. Chem Commun (Camb). 2015; 51(62):12490-3. DOI: 10.1039/c5cc03807c. View

Zhang Y, Fu H, Liu D, An J, Gao H . Construction of biocompatible bovine serum albumin nanoparticles composed of nano graphene oxide and AIEgen for dual-mode phototherapy bacteriostatic and bacterial tracking. J Nanobiotechnology. 2019; 17(1):104. PMC: 6785860. DOI: 10.1186/s12951-019-0523-x. View

Nobrega F, Vlot M, de Jonge P, Dreesens L, Beaumont H, Lavigne R . Targeting mechanisms of tailed bacteriophages. Nat Rev Microbiol. 2018; 16(12):760-773. DOI: 10.1038/s41579-018-0070-8. View

Linder K, Malani P . Meningococcal Meningitis. JAMA. 2019; 321(10):1014. DOI: 10.1001/jama.2019.0772. View

10.

Borjihan Q, Wu H, Dong A, Gao H, Yang Y . AIEgens for Bacterial Imaging and Ablation. Adv Healthc Mater. 2021; 10(24):e2100877. DOI: 10.1002/adhm.202100877. View

11.

Bai H, He W, Chau J, Zheng Z, Kwok R, Lam J . AIEgens for microbial detection and antimicrobial therapy. Biomaterials. 2020; 268:120598. DOI: 10.1016/j.biomaterials.2020.120598. View

12.

Pan Y, Gao Y, Hu J, Ye G, Zhou F, Yan C . Montmorillonite nanosheets with enhanced photodynamic performance for synergistic bacterial ablation. J Mater Chem B. 2020; 9(2):404-409. DOI: 10.1039/d0tb02254c. View

13.

Skwarecki A, Milewski S, Schielmann M, Milewska M . Antimicrobial molecular nanocarrier-drug conjugates. Nanomedicine. 2016; 12(8):2215-2240. DOI: 10.1016/j.nano.2016.06.002. View

14.

Makabenta J, Nabawy A, Li C, Schmidt-Malan S, Patel R, Rotello V . Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections. Nat Rev Microbiol. 2020; 19(1):23-36. PMC: 8559572. DOI: 10.1038/s41579-020-0420-1. View

15.

Yan D, Xie W, Zhang J, Wang L, Wang D, Tang B . Donor/π-Bridge Manipulation for Constructing a Stable NIR-II Aggregation-Induced Emission Luminogen with Balanced Phototheranostic Performance*. Angew Chem Int Ed Engl. 2021; 60(51):26769-26776. DOI: 10.1002/anie.202111767. View

16.

Brockhurst M, Morgan A, Fenton A, Buckling A . Experimental coevolution with bacteria and phage. The Pseudomonas fluorescens--Phi2 model system. Infect Genet Evol. 2007; 7(4):547-52. DOI: 10.1016/j.meegid.2007.01.005. View

17.

Ji H, Dong K, Yan Z, Ding C, Chen Z, Ren J . Bacterial Hyaluronidase Self-Triggered Prodrug Release for Chemo-Photothermal Synergistic Treatment of Bacterial Infection. Small. 2016; 12(45):6200-6206. DOI: 10.1002/smll.201601729. View

18.

Chu L, Gao H, Cheng T, Zhang Y, Liu J, Huang F . A charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotic delivery. Chem Commun (Camb). 2016; 52(37):6265-8. DOI: 10.1039/c6cc01269h. View

19.

Deng Y, Jia F, Chen S, Shen Z, Jin Q, Fu G . Nitric oxide as an all-rounder for enhanced photodynamic therapy: Hypoxia relief, glutathione depletion and reactive nitrogen species generation. Biomaterials. 2018; 187:55-65. DOI: 10.1016/j.biomaterials.2018.09.043. View

20.

Wang W, Wu F, Zhang Q, Zhou N, Zhang M, Zheng T . Aggregation-Induced Emission Nanoparticles for Single Near-Infrared Light-Triggered Photodynamic and Photothermal Antibacterial Therapy. ACS Nano. 2022; 16(5):7961-7970. DOI: 10.1021/acsnano.2c00734. View