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New Bisabolane-Type Sesquiterpenoids from and Their Anti-Atherosclerotic Activity

Overview

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Mar 29

PMID 36985676

Authors

Authors

Yu-Qin Guo

Guang-Xu Wu

Cheng Peng

Yun-Qiu Fan

Lei Li

Fei Liu

Liang Xiong

Affiliations

Affiliations

Soon will be listed here.

Abstract

To explore the sesquiterpenoids in L. and their activity related to anti-atherosclerosis. The chemical compounds of the rhizomes of were separated and purified by multiple chromatography techniques. Their structures were established by a variety of spectroscopic experiments. The absolute configurations were determined by comparing experimental and calculated NMR chemical shifts and electronic circular dichroism (ECD) spectra. Their anti-inflammatory effects and inhibitory activity against macrophage-derived foam cell formation were evaluated by lipopolysaccharide (LPS) and oxidized low-density lipoprotein (ox-LDL)-injured RAW264.7 macrophages, respectively. This study resulted in the isolation of 10 bisabolane-type sesquiterpenoids (-) from , including two pairs of new epimers (curbisabolanones A-D, -). Compound significantly inhibited LPS-induced nitric oxide (NO), interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and prostaglandin E2 (PGE2) production in RAW264.7 cells. Furthermore, compound showed inhibitory activity against macrophage-derived foam cell formation, which was represented by markedly reducing ox-LDL-induced intracellular lipid accumulation as well as total cholesterol (TC), free cholesterol (FC), and cholesterol ester (CE) contents in RAW264.7 cells. These findings suggest that bisabolane-type sesquiterpenoids, one of the main types of components in , have the potential to alleviate the atherosclerosis process by preventing inflammation and inhibiting macrophage foaming.

Citing Articles

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PMID: 37623841 PMC: 10456799. DOI: 10.3390/metabo13080898.

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