Antimicrobial and Antioxidant Properties of Chemically Analyzed Essential Oil of L. (Asteraceae) Native to Mediterranean Area

Overview

Journal Life (Basel)

Specialty Biology

Date 2023 Mar 29

PMID 36983962

Authors

Khalid Chebbac

Zineb Benziane Ouaritini

Abdelfattah El Moussaoui

Mohammed Chalkha

Soufyane Lafraxo

Yousef A Bin Jardan

Hiba-Allah Nafidi

Mohammed Bourhia

Raja Guemmouh

Affiliations

Soon will be listed here.

Abstract

(AA) is an aromatic plant belonging to the family, which has long been known for its several medicinal virtues. In addition, essential oils (EOs) extracted from AA have a wide range of therapeutic properties. Therefore, this study aimed to investigate the phytochemical composition, anti-microbial, and anti-oxidant properties of essential oil (EOAA). EO was extracted, and its chemical constituents were ascertained by the use of GC-MS analysis. EOAA shows remarkable antioxidant capacities of DPPH free radical scavenging with an IC value of 29 ± 5.3 μg/mL and ferric reducing antioxidant power with an EC value of 9.21 ± 0.3 µg/mL, and it also has a good total antioxidant capacity of 911.59 ± 115.71 milligrams of ascorbic acid equivalence per gram of EO (mg AAE/g EO). Moreover, the in vitro antimicrobial screening results indicate that EOAA has shown promising antibacterial activity, especially against the strain, and it also shows significant antifungal activity against and yeasts. Taken together, our findings highlight the importance of EOAA as a source of strong antioxidant and antimicrobial agents, which could be used as an alternative form to control free radicals and combat drug-resistant microbes.

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References

Yu Z, Tang J, Khare T, Kumar V . The alarming antimicrobial resistance in ESKAPEE pathogens: Can essential oils come to the rescue?. Fitoterapia. 2019; 140:104433. DOI: 10.1016/j.fitote.2019.104433. View

Maggio A, Rosselli S, Bruno M, Spadaro V, Raimondo F, Senatore F . Chemical composition of essential oil from Italian populations of Artemisia alba Turra (Asteraceae). Molecules. 2012; 17(9):10232-41. PMC: 6269043. DOI: 10.3390/molecules170910232. View

Sarker S, Nahar L, Kumarasamy Y . Microtitre plate-based antibacterial assay incorporating resazurin as an indicator of cell growth, and its application in the in vitro antibacterial screening of phytochemicals. Methods. 2007; 42(4):321-4. PMC: 1895922. DOI: 10.1016/j.ymeth.2007.01.006. View

Yuan H, Ma Q, Ye L, Piao G . The Traditional Medicine and Modern Medicine from Natural Products. Molecules. 2016; 21(5). PMC: 6273146. DOI: 10.3390/molecules21050559. View

Pisoschi A, Pop A, Iordache F, Stanca L, Predoi G, Serban A . Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status. Eur J Med Chem. 2020; 209:112891. DOI: 10.1016/j.ejmech.2020.112891. View

Rashid M, Alamzeb M, Ali S, Ullah Z, Shah Z, Naz I . The chemistry and pharmacology of alkaloids and allied nitrogen compounds from Artemisia species: A review. Phytother Res. 2019; 33(10):2661-2684. DOI: 10.1002/ptr.6466. View

Gruessner B, Cornet-Vernet L, Desrosiers M, Lutgen P, Towler M, Weathers P . It is not just artemisinin: sp. for treating diseases including malaria and schistosomiasis. Phytochem Rev. 2021; 18(6):1509-1527. PMC: 8078015. DOI: 10.1007/s11101-019-09645-9. View

Bloom D, Cadarette D . Infectious Disease Threats in the Twenty-First Century: Strengthening the Global Response. Front Immunol. 2019; 10:549. PMC: 6447676. DOI: 10.3389/fimmu.2019.00549. View

Lafraxo S, El Moussaoui A, Bin Jardan Y, El Barnossi A, Chebaibi M, Baammi S . GC-MS Profiling, Antioxidant, Antimicrobial, and NADPH Oxidase Inhibition Studies of Essential Oil of Bark. Evid Based Complement Alternat Med. 2022; 2022:6305672. PMC: 9532082. DOI: 10.1155/2022/6305672. View

10.

Thomas V, Brown R, Ashcraft D, Pankey G . Synergistic effect between nisin and polymyxin B against pandrug-resistant and extensively drug-resistant Acinetobacter baumannii. Int J Antimicrob Agents. 2019; 53(5):663-668. DOI: 10.1016/j.ijantimicag.2019.03.009. View

11.

Amrati F, Bourhia M, Saghrouchni H, Slighoua M, Grafov A, Ullah R . (Guss.) N.E.Br.: Anti-Inflammatory, Antifungal, and Antibacterial Activities against Nosocomial Antibiotic-Resistant Microbes of Chemically Characterized Fractions. Molecules. 2021; 26(3). PMC: 7865290. DOI: 10.3390/molecules26030636. View

12.

Bakkali F, Averbeck S, Averbeck D, Idaomar M . Biological effects of essential oils--a review. Food Chem Toxicol. 2007; 46(2):446-75. DOI: 10.1016/j.fct.2007.09.106. View

13.

Burt S . Essential oils: their antibacterial properties and potential applications in foods--a review. Int J Food Microbiol. 2004; 94(3):223-53. DOI: 10.1016/j.ijfoodmicro.2004.03.022. View

14.

Ornano L, Venditti A, Ballero M, Sanna C, Quassinti L, Bramucci M . Chemopreventive and antioxidant activity of the chamazulene-rich essential oil obtained from Artemisia arborescens L. growing on the Isle of La Maddalena, Sardinia, Italy. Chem Biodivers. 2013; 10(8):1464-74. DOI: 10.1002/cbdv.201200435. View

15.

Vouga M, Greub G . Emerging bacterial pathogens: the past and beyond. Clin Microbiol Infect. 2015; 22(1):12-21. PMC: 7128729. DOI: 10.1016/j.cmi.2015.10.010. View

16.

Catalano A, Iacopetta D, Ceramella J, Scumaci D, Giuzio F, Saturnino C . Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies. Molecules. 2022; 27(3). PMC: 8839222. DOI: 10.3390/molecules27030616. View

17.

Trendafilova A, Moujir L, Sousa P, Seca A . Research Advances on Health Effects of Edible Species and Some Sesquiterpene Lactones Constituents. Foods. 2021; 10(1). PMC: 7823681. DOI: 10.3390/foods10010065. View

18.

Aruoma O . Free radicals, oxidative stress, and antioxidants in human health and disease. J Am Oil Chem Soc. 2020; 75(2):199-212. PMC: 7101596. DOI: 10.1007/s11746-998-0032-9. View

19.

Habibi Z, Ghanian S, Ghasemi S, Yousefi M . Chemical composition and antibacterial activity of the volatile oil from seeds of Artemisia annua L. from Iran. Nat Prod Res. 2012; 27(2):198-200. DOI: 10.1080/14786419.2012.662652. View

20.

Suurbaar J, Mosobil R, Donkor A . Antibacterial and antifungal activities and phytochemical profile of leaf extract from different extractants of Ricinus communis against selected pathogens. BMC Res Notes. 2017; 10(1):660. PMC: 5709865. DOI: 10.1186/s13104-017-3001-2. View