Apple Peel Supplementation Potential in Metabolic Syndrome Prevention

Overview

Journal Life (Basel)

Specialty Biology

Date 2023 Mar 29

PMID 36983908

Authors

Joanna Popiolek-Kalisz

Pawel Glibowski

Affiliations

Soon will be listed here.

Abstract

(1) Introduction: Apples are a source of bioactive substances, e.g., anthocyanidins and flavonols, and dietary fiber. Their highest concentrations are observed in the skin. Metabolic syndrome (MetS) is a set of conditions originally associated with obesity. Excessive adipose tissue accompanying obesity leads to chronic inflammation and metabolic disorders, which result in the development of dyslipidemia, elevated blood pressure, and glucose levels. Thus, supplementation of apple peels, a source of antioxidant substances and fiber, could potentially be a method supporting the prevention of MetS. This paper summarizes the results of available research on the potential impact of apple peel supplementation on the components of MetS. (2) Results: The results from in vitro and animal model studies indicate a positive effect of apple peel supplementation on lipid profile, glucose levels, and blood pressure regulation mediators. Only one human study was performed, and it showed that the consumption of apple peels had an effect on endothelial function but not on other clinical parameters. At the moment, there are no results from observations on large groups of people available. (3) Conclusions: The results of in vitro and animal-model studies indicate the potential of apple peel supplementation in MetS prevention, but it has not been clinically confirmed in human studies. Conducting large human studies could allow a definite clarification of the role of apple peel supplementation in MetS prevention.

References

Lee K, Park E, Lee H, Kim M, Cha Y, Kim J . Effects of daily quercetin-rich supplementation on cardiometabolic risks in male smokers. Nutr Res Pract. 2011; 5(1):28-33. PMC: 3061266. DOI: 10.4162/nrp.2011.5.1.28. View

Du H, van der A D, Boshuizen H, Forouhi N, Wareham N, Halkjaer J . Dietary fiber and subsequent changes in body weight and waist circumference in European men and women. Am J Clin Nutr. 2009; 91(2):329-36. DOI: 10.3945/ajcn.2009.28191. View

Raposo L . Metabolic syndrome in Poland: the WOBASZ II study. Pol Arch Intern Med. 2021; 131(6):501-502. DOI: 10.20452/pamw.16040. View

Rasmusssen R, Poulsen M, Hansen H . Distribution of multiple pesticide residues in apple segments after home processing. Food Addit Contam. 2003; 20(11):1044-63. DOI: 10.1080/02652030310001615221. View

Withrow D, Alter D . The economic burden of obesity worldwide: a systematic review of the direct costs of obesity. Obes Rev. 2010; 12(2):131-41. DOI: 10.1111/j.1467-789X.2009.00712.x. View

. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018; 392(10159):1736-1788. PMC: 6227606. DOI: 10.1016/S0140-6736(18)32203-7. View

Garcia A, Otto B, Reich S, Weickert M, Steiniger J, Machowetz A . Arabinoxylan consumption decreases postprandial serum glucose, serum insulin and plasma total ghrelin response in subjects with impaired glucose tolerance. Eur J Clin Nutr. 2006; 61(3):334-41. DOI: 10.1038/sj.ejcn.1602525. View

Eckel R, Alberti K, Grundy S, Zimmet P . The metabolic syndrome. Lancet. 2010; 375(9710):181-3. DOI: 10.1016/S0140-6736(09)61794-3. View

Gil-Cardoso K, Gines I, Pinent M, Ardevol A, Blay M, Terra X . Effects of flavonoids on intestinal inflammation, barrier integrity and changes in gut microbiota during diet-induced obesity. Nutr Res Rev. 2016; 29(2):234-248. DOI: 10.1017/S0954422416000159. View

10.

Visseren F, Mach F, Smulders Y, Carballo D, Koskinas K, Back M . 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021; 42(34):3227-3337. DOI: 10.1093/eurheartj/ehab484. View

11.

Ghadge A, Khaire A, Kuvalekar A . Adiponectin: A potential therapeutic target for metabolic syndrome. Cytokine Growth Factor Rev. 2018; 39:151-158. DOI: 10.1016/j.cytogfr.2018.01.004. View

12.

Ko D, Ku K . Effect of Anti-Obesity and Antioxidant Activity through the Additional Consumption of Peel from 'Fuji' Pre-Washed Apple. Foods. 2022; 11(4). PMC: 8871014. DOI: 10.3390/foods11040497. View

13.

Wolfe K, Wu X, Liu R . Antioxidant activity of apple peels. J Agric Food Chem. 2003; 51(3):609-14. DOI: 10.1021/jf020782a. View

14.

Thilakarathna S, Rupasinghe H, Needs P . Apple peel bioactive rich extracts effectively inhibit in vitro human LDL cholesterol oxidation. Food Chem. 2012; 138(1):463-70. DOI: 10.1016/j.foodchem.2012.09.121. View

15.

Henriquez C, Speisky H, Chiffelle I, Valenzuela T, Araya M, Simpson R . Development of an ingredient containing apple peel, as a source of polyphenols and dietary fiber. J Food Sci. 2010; 75(6):H172-81. DOI: 10.1111/j.1750-3841.2010.01700.x. View

16.

Hollaender P, Ross A, Kristensen M . Whole-grain and blood lipid changes in apparently healthy adults: a systematic review and meta-analysis of randomized controlled studies. Am J Clin Nutr. 2015; 102(3):556-72. DOI: 10.3945/ajcn.115.109165. View

17.

Patel P, Abate N . Body fat distribution and insulin resistance. Nutrients. 2013; 5(6):2019-27. PMC: 3725490. DOI: 10.3390/nu5062019. View

18.

Barber T, Kabisch S, Pfeiffer A, Weickert M . The Health Benefits of Dietary Fibre. Nutrients. 2020; 12(10). PMC: 7589116. DOI: 10.3390/nu12103209. View

19.

Popiolek-Kalisz J, Fornal E . The Effects of Quercetin Supplementation on Blood Pressure - Meta-Analysis. Curr Probl Cardiol. 2022; 47(11):101350. DOI: 10.1016/j.cpcardiol.2022.101350. View

20.

Mattioli R, Francioso A, Mosca L, Silva P . Anthocyanins: A Comprehensive Review of Their Chemical Properties and Health Effects on Cardiovascular and Neurodegenerative Diseases. Molecules. 2020; 25(17). PMC: 7504512. DOI: 10.3390/molecules25173809. View