Targeted Therapy for Orofacial Pain: A Novel Perspective for Precision Medicine

Overview

Journal J Pers Med

Date 2023 Mar 29

PMID 36983746

Authors

Swarnalakshmi Raman

Daisuke Ikutame

Kazuo Okura

Yoshizo Matsuka

Affiliations

Soon will be listed here.

Abstract

Orofacial pain (OFP) is a dental specialty that includes the diagnosis, management and treatment of disorders of the jaw, mouth, face, head and neck. Evidence-based understanding is critical in effectively treating OFPs as the pathophysiology of these conditions is multifactorial. Since OFP impacts the quality of life of the affected individuals, treating patients successfully is of the utmost significance. Despite the therapeutic choices available, treating OFP is still quite challenging, owing to inter-patient variations. The emerging trends in precision medicine could probably lead us to a paradigm shift in effectively managing the untreatable long-standing pain conditions. Precision medicine is designed based on the patient's genetic profile to meet their needs. Several significant relationships have been discovered based on the genetics and genomics of pain in the past, and some of the notable targets are discussed in this review. The scope of this review is to discuss preclinical and clinical trials that include approaches used in targeted therapy for orofacial pain. Future developments in pain medicine should benefit from current trends in research into novel therapeutic approaches.

Citing Articles

Development and Evaluation of a GPT4-Based Orofacial Pain Clinical Decision Support System.

Vueghs C, Shakeri H, Renton T, Van der Cruyssen F Diagnostics (Basel). 2025; 14(24.

PMID: 39767196 PMC: 11674870. DOI: 10.3390/diagnostics14242835.

Enhancing orofacial pain relief: α-phellandrene complexed with hydroxypropyl-β-cyclodextrin mitigates orofacial nociception in rodents.

Machado B, Passos F, Antoniolli A, Menezes Pereira E, Santos T, Monteiro B Naunyn Schmiedebergs Arch Pharmacol. 2024; .

PMID: 39495266 DOI: 10.1007/s00210-024-03561-2.

Advancements in Understanding and Classifying Chronic Orofacial Pain: Key Insights from Biopsychosocial Models and International Classifications (ICHD-3, ICD-11, ICOP).

Canfora F, Ottaviani G, Calabria E, Pecoraro G, Leuci S, Coppola N Biomedicines. 2023; 11(12).

PMID: 38137487 PMC: 10741077. DOI: 10.3390/biomedicines11123266.

References

Rotpenpian N, Yakkaphan P . Review of Literatures: Physiology of Orofacial Pain in Dentistry. eNeuro. 2021; 8(2). PMC: 8086974. DOI: 10.1523/ENEURO.0535-20.2021. View

Cornelison L, Woodman S, Durham P . 5-HT3/7 and GABA receptors mediate inhibition of trigeminal nociception by dietary supplementation of grape seed extract. Nutr Neurosci. 2021; 25(8):1565-1576. PMC: 8339147. DOI: 10.1080/1028415X.2021.1880211. View

Demartini C, Greco R, Zanaboni A, Francesconi O, Nativi C, Tassorelli C . Antagonism of Transient Receptor Potential Ankyrin Type-1 Channels as a Potential Target for the Treatment of Trigeminal Neuropathic Pain: Study in an Animal Model. Int J Mol Sci. 2018; 19(11). PMC: 6274796. DOI: 10.3390/ijms19113320. View

Garcia-Carmona J, Georgiou P, Zanos P, Bailey A, Laorden M . Methamphetamine withdrawal induces activation of CRF neurons in the brain stress system in parallel with an increased activity of cardiac sympathetic pathways. Naunyn Schmiedebergs Arch Pharmacol. 2018; 391(4):423-434. DOI: 10.1007/s00210-018-1470-z. View

Dickenson A, Patel R . Translational issues in precision medicine in neuropathic pain. Can J Pain. 2020; 4(1):30-38. PMC: 7077367. DOI: 10.1080/24740527.2020.1720502. View

Raman S, Waskitho A, Raju R, Iwasa T, Ikutame D, Okura K . Analgesic Effect of Tranilast in an Animal Model of Neuropathic Pain and Its Role in the Regulation of Tetrahydrobiopterin Synthesis. Int J Mol Sci. 2022; 23(11). PMC: 9180260. DOI: 10.3390/ijms23115878. View

McCleane G, Suzuki R, Dickenson A . Does a single intravenous injection of the 5HT3 receptor antagonist ondansetron have an analgesic effect in neuropathic pain? A double-blinded, placebo-controlled cross-over study. Anesth Analg. 2003; 97(5):1474-1478. DOI: 10.1213/01.ANE.0000085640.69855.51. View

Al-Karagholi M, Hansen J, Guo S, Olesen J, Ashina M . Opening of ATP-sensitive potassium channels causes migraine attacks: a new target for the treatment of migraine. Brain. 2019; 142(9):2644-2654. DOI: 10.1093/brain/awz199. View

Ginsburg G, Phillips K . Precision Medicine: From Science To Value. Health Aff (Millwood). 2018; 37(5):694-701. PMC: 5989714. DOI: 10.1377/hlthaff.2017.1624. View

10.

Pak D, Yong R, Kaye A, Urman R . Chronification of Pain: Mechanisms, Current Understanding, and Clinical Implications. Curr Pain Headache Rep. 2018; 22(2):9. DOI: 10.1007/s11916-018-0666-8. View

11.

Gibson W . Can personalized medicine survive?. Can Fam Physician. 2010; 17(8):29-88. PMC: 2370041. View

12.

Ungerer M, Knezovich J, Ramsay M . In utero alcohol exposure, epigenetic changes, and their consequences. Alcohol Res. 2013; 35(1):37-46. PMC: 3860424. View

13.

Peck R . Precision Medicine Is Not Just Genomics: The Right Dose for Every Patient. Annu Rev Pharmacol Toxicol. 2017; 58:105-122. DOI: 10.1146/annurev-pharmtox-010617-052446. View

14.

Branford R, Droney J, Ross J . Opioid genetics: the key to personalized pain control?. Clin Genet. 2012; 82(4):301-10. DOI: 10.1111/j.1399-0004.2012.01923.x. View

15.

Somogyi A, Musolino S, Barratt D . New pharmacological perspectives and therapeutic options for opioids: Differences matter. Anaesth Intensive Care. 2022; 50(1-2):127-140. DOI: 10.1177/0310057X211063891. View

16.

Smith P . K Channels in Primary Afferents and Their Role in Nerve Injury-Induced Pain. Front Cell Neurosci. 2020; 14:566418. PMC: 7528628. DOI: 10.3389/fncel.2020.566418. View

17.

Sessle B . Chronic Orofacial Pain: Models, Mechanisms, and Genetic and Related Environmental Influences. Int J Mol Sci. 2021; 22(13). PMC: 8268972. DOI: 10.3390/ijms22137112. View

18.

Abd-Elsayed A, Jackson M, Gu S, Fiala K, Gu J . Neuropathic pain and Kv7 voltage-gated potassium channels: The potential role of Kv7 activators in the treatment of neuropathic pain. Mol Pain. 2019; 15:1744806919864256. PMC: 6659175. DOI: 10.1177/1744806919864256. View

19.

Darnaudery M, Maccari S . Epigenetic programming of the stress response in male and female rats by prenatal restraint stress. Brain Res Rev. 2008; 57(2):571-85. DOI: 10.1016/j.brainresrev.2007.11.004. View

20.

Kotecha M, Cheshire W, Finnigan H, Giblin K, Naik H, Palmer J . Design of Phase 3 Studies Evaluating Vixotrigine for Treatment of Trigeminal Neuralgia. J Pain Res. 2020; 13:1601-1609. PMC: 7335847. DOI: 10.2147/JPR.S247182. View