The Relationship of and Variants with Response Rate and Survival Taking into Account Thalidomide/Bortezomib Treatment in Patients with Multiple Myeloma

(1) Background: Chemokines and chemokine receptors play an important role in tumor development. The aim of this study was to check the significance of and variants with response rate, survival, and the level of regulated on activation, normal T cells expressed and secreted (RANTES/CCL5) in multiple myeloma (MM) patients; (2) Methods: Genomic DNA from 101 newly diagnosed MM patients and 100 healthy blood donors were analyzed by Real-time PCR method (for and genotyping). In a subgroup of 70 MM patients, serum samples were collected to determine the level of RANTES; (3) Results: multivariate Cox regression showed increased risk of disease relapse or progression (HR = 4.77; = 0.01) in MM patients with CG + CC genotypes of rs2280788. In contrast, CT + TT genotypes of rs2107538 were associated withdecreased risk of death (HR = 0.18; = 0.028) and disease relapse or progression (HR = 0.26; = 0.01). In MM patients with major genotypes of rs2280789, rs2280788, and rs2107538, higher survival rates were observed in response to treatment with thalidomide and bortezomib. Statistically significant lower RANTES levels were seen in minor genotypes and heterozygotes of and variants; (4) Conclusions: Major genotypes of variants may be independent positive prognostic factors in MM.