» Articles » PMID: 36983115

Platelet-Rich Plasma and Acellular Dermal Matrix in the Surgical Treatment of Hidradenitis Suppurativa: A Comparative Retrospective Study

Overview
Journal J Clin Med
Specialty General Medicine
Date 2023 Mar 29
PMID 36983115
Authors
Affiliations
Soon will be listed here.
Abstract

(1) Introduction: Hidradenitis suppurativa (HS) is an inflammatory skin disease with recurrent, chronic, painful, and purulent skin lesions. Topical or systemic antibiotics are the most widely used treatments for the management of mild stages of the disease. In chronic cases (Hurley II/III), wide excision of lesions should be considered. During reconstructive surgery, the most problematic aspect is wound closure. Very large excisional wounds require reconstructive techniques such as skin flaps, skin grafts, or both. Surgical methods have their limitations, so reconstructive methods in HS surgery need to be continuously improved through the use of, for example, platelet-rich plasma and acellular dermal matrix; (2) Methods: The aim of this study was to evaluate the clinical outcomes and efficacy of surgical treatment of patients with HS using local skin flaps injected with PRP compared to a group of local skin flaps without platelet-rich plasma injection, an acellular dermal matrix, and split-thickness skin graft co-grafts. Sixty-one patients (29 males and 32 females) were included in the study. Most patients were characterized by Hurley grade III HS; (3) Results: The use of PRP injection in reconstructions (skin flaps) improved healing and reduced the number of complications, a notable trend in this study. A co-graft of acellular dermal matrix and split-thickness skin graft gave better therapeutic results than split-thickness skin graft alone (fewer days in hospital, fewer postoperative complications); (4) Conclusions: PRP injected into skin flaps, co-grafted acellular dermal matrix, and split-thickness skin grafts are good options for the surgical treatment of hidradenitis suppurativa.

Citing Articles

Bilateral Superior Gluteal Artery Perforator (SGAP) Flap: Modified Concept in Perineal Reconstruction.

Zaussinger M, Pommer G, Freller K, Schmidt M, Huemer G J Clin Med. 2024; 13(13).

PMID: 38999391 PMC: 11242694. DOI: 10.3390/jcm13133825.


A Novel Prehydrated Porcine-Derived Acellular Dermal Matrix: A Histological and Clinical Evaluation.

van Orten A, Goetz W, Bilhan H Int J Biomater. 2024; 2024:7322223.

PMID: 38966862 PMC: 11223909. DOI: 10.1155/2024/7322223.


Evaluation of Esthetic Results after Mass Removal with Elliptical Skin Excision Using Ultrasonography to Measure Skin Thickness.

Woo S, Gwak H, Kim K, Lee J, Choi J, Suh I J Clin Med. 2024; 13(5).

PMID: 38592681 PMC: 10935000. DOI: 10.3390/jcm13051467.


Therapeutic TNF Inhibitors Exhibit Differential Levels of Efficacy in Accelerating Cutaneous Wound Healing.

Cao Y, Harvey B, Jin L, Westmoreland S, Wang J, Puri M JID Innov. 2024; 4(1):100250.

PMID: 38226320 PMC: 10788510. DOI: 10.1016/j.xjidi.2023.100250.


Intraoperative Blood Flow Analysis of Free Flaps with Arteriovenous Loops for Autologous Microsurgical Reconstruction.

Geierlehner A, Horch R, Ludolph I, Lang W, Rother U, Meyer A J Clin Med. 2023; 12(23).

PMID: 38068529 PMC: 10707281. DOI: 10.3390/jcm12237477.


References
1.
Kazakos K, Lyras D, Verettas D, Tilkeridis K, Tryfonidis M . The use of autologous PRP gel as an aid in the management of acute trauma wounds. Injury. 2008; 40(8):801-5. DOI: 10.1016/j.injury.2008.05.002. View

2.
Nazzaro G, Passoni E, Guanziroli E, Casazza G, Muratori S, Barbareschi M . Comparison of clinical and sonographic scores in a cohort of 140 patients with hidradenitis suppurativa from an Italian referral centre: a retrospective observational study. Eur J Dermatol. 2018; 28(6):845-847. DOI: 10.1684/ejd.2018.3430. View

3.
Collier E, Parvataneni R, Lowes M, Naik H, Okun M, Shi V . Diagnosis and management of hidradenitis suppurativa in women. Am J Obstet Gynecol. 2020; 224(1):54-61. PMC: 8163033. DOI: 10.1016/j.ajog.2020.09.036. View

4.
Lee Y, Park M, Park D, Hahn H, Kim S, Lee I . Effectiveness of Acellular Dermal Matrix on Autologous Split-Thickness Skin Graft in Treatment of Deep Tissue Defect: Esthetic Subjective and Objective Evaluation. Aesthetic Plast Surg. 2017; 41(5):1049-1057. DOI: 10.1007/s00266-017-0891-2. View

5.
Scuderi N, Monfrecola A, Dessy L, Fabbrocini G, Megna M, Monfrecola G . Medical and Surgical Treatment of Hidradenitis Suppurativa: A Review. Skin Appendage Disord. 2017; 3(2):95-110. PMC: 5436059. DOI: 10.1159/000462979. View