Programming Factors of Neonatal Intestinal Dysbiosis As a Cause of Disease

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Mar 29

PMID 36982799

Authors

Miljana Z Jovandaric

Stefan Dugalic

Sandra Babic

Ivana R Babovic

Srboljub Milicevic

Dejan Mihajlovic

Miljan Culjic

Tamara Zivanovic

Aleksandar Trklja

Bogdan Markovic

Vera Plesinac

Zorica Jestrovic

Biljana Medjo

Misela Raus

Miroslava Gojnic Dugalic

Affiliations

Soon will be listed here.

Abstract

The intestinal microbiota consists of trillions of bacteria, viruses, and fungi that achieve a perfect symbiosis with the host. They perform immunological, metabolic, and endocrine functions in the body. The microbiota is formed intrauterine. Dysbiosis is a microbiome disorder characterized by an imbalance in the composition of the microbiota, as well as changes in their functional and metabolic activities. The causes of dysbiosis include improper nutrition in pregnant women, hormone therapy, the use of drugs, especially antibiotics, and a lack of exposure to the mother's vaginal microbiota during natural birth. Changes in the intestinal microbiota are increasingly being identified in various diseases, starting in the early neonatal period into the adult period. Conclusions: In recent years, it has become more and more obvious that the components of the intestinal microbiota are crucial for the proper development of the immune system, and its disruption leads to disease.

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