BAG3: Nature's Quintessential Multi-Functional Protein Functions As a Ubiquitous Intra-Cellular Glue

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2023 Mar 29

PMID 36980278

Authors

Caitlyn M Brenner

Muaaz Choudhary

Michael G McCormick

David Cheung

Gavin P Landesberg

Ju-Fang Wang

Jianliang Song

Thomas G Martin

Joseph Y Cheung

Hui-Qi Qu

Hakon Hakonarson

Arthur M Feldman

Affiliations

Soon will be listed here.

Abstract

BAG3 is a 575 amino acid protein that is found throughout the animal kingdom and homologs have been identified in plants. The protein is expressed ubiquitously but is most prominent in cardiac muscle, skeletal muscle, the brain and in many cancers. We describe BAG3 as a quintessential multi-functional protein. It supports autophagy of both misfolded proteins and damaged organelles, inhibits apoptosis, maintains the homeostasis of the mitochondria, and facilitates excitation contraction coupling through the L-type calcium channel and the beta-adrenergic receptor. High levels of BAG3 are associated with insensitivity to chemotherapy in malignant cells whereas both loss of function and gain of function variants are associated with cardiomyopathy.

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