The Influence of Exercise-Associated Small Extracellular Vesicles on Trophoblasts

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2023 Mar 29

PMID 36979835

Authors

Shuhiba Mohammad

Jayonta Bhattacharjee

Velislava Tzaneva

Kelly Ann Hutchinson

Madeeha Shaikh

Danilo Fernandes da Silva

Dylan Burger

Kristi B Adamo

Affiliations

Soon will be listed here.

Abstract

Exercise induces the release of small extracellular vesicles (sEVs) into circulation that are postulated to mediate tissue cross-talk during exercise. We previously reported that pregnant individuals released greater levels of sEVs into circulation after exercise compared to matched non-pregnant controls, but their biological functions remain unknown. In this study, sEVs isolated from the plasma of healthy pregnant and non-pregnant participants after a single bout of moderate-intensity exercise were evaluated for their impact on trophoblasts . Exercise-associated sEVs were found localized within the cytoplasm of BeWo choriocarcinoma cells, used to model trophoblasts in vitro. Exposure to exercise-associated sEVs did not significantly alter BeWo cell proliferation, gene expression of angiogenic growth factors and , or the release of the hormone human chorionic gonadotropin. The results from this pilot study support that exercise-associated sEVs could interact with trophoblasts in vitro, and warrant further investigation to reveal their potential role in communicating the effects of exercise to the maternal-fetal interface.

Citing Articles

Effect of exercise during pregnancy on offspring development through ameliorating high glucose and hypoxia in gestational diabetes mellitus.

Tang Y, Wang L, Wu Y, Zhang L, Hu L, Wu Q World J Diabetes. 2024; 15(11):2203-2219.

PMID: 39582571 PMC: 11580567. DOI: 10.4239/wjd.v15.i11.2203.

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