Green Synthesis of Silver Nanoparticles Using the Leaf Extract of the Medicinal Plant, and Its Antibacterial, Antiangiogenic, Anticancer and Catalytic Properties

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2023 Mar 29

PMID 36978431

Authors

Anthyalam Parambil Ajaykumar

Anjaly Mathew

Ayanam Parambath Chandni

Sudhir Rama Varma

Kodangattil Narayanan Jayaraj

Ovungal Sabira

Vazhanthodi Abdul Rasheed

Valiyaparambil Sivadasan Binitha

Thangaraj Raja Swaminathan

Valaparambil Saidumohammad Basheer

Suvendu Giri

Suvro Chatterjee

Affiliations

Soon will be listed here.

Abstract

Silver nanoparticles (AgNPs) made by green synthesis offer a variety of biochemical properties and are an excellent alternative to traditional medications due to their low cost. In the current study, we synthesised AgNPs from the leaf extract of the medicinal plant , commonly called narumpanal. The nanoparticles were characterised by ultraviolet-visible (UV-Vis) spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). SEM analysis showed AgNPs are highly crystalline and spherical with an average diameter of 7.13 nm. The outstanding catalytic activity of AgNPs was demonstrated by employing the reduction of 4-nitrophenol to 4-aminophenol. The AgNPs showed antiangiogenic activity in the chick chorioallantoic membrane (CAM) assay. AgNPs demonstrated anticancer activity against Dalton's lymphoma ascites cells (DLA cells) in trypan blue assay and cytotoxicity against three fish cell lines: liver (onlL; National Repository of Fish Cell Lines, India (NRFC) Accession number-NRFC052) cells, koi fin (CCKF; NRFC Accession number-NRFC007) cells and gill (CyCKG; NRFC Accession number-NRFC064). Furthermore, the AgNPs demonstrated their ability to inhibit pathogenic microorganisms, , and The results from the study displayed green synthesised AgNPs exhibit antiangiogenic activity, cytotoxicity, antimicrobial and catalytic properties, which are crucial characteristics of a molecule with excellent clinical applications.

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