Comparative Evaluation of Adhesion to a Poly-(2-Methacryloyloxyethyl Phosphorylcholine)-Modified Silicone Hydrogel Contact Lens

Overview

Journal Vision (Basel)

Specialty Ophthalmology

Date 2023 Mar 28

PMID 36977307

Authors

Valerie Harris

Reed Pifer

Paul Shannon

Monica Crary

Affiliations

Soon will be listed here.

Abstract

is the most common causative agent associated with microbial keratitis. During contact lens wear, pathogens may be introduced into the ocular environment, which might cause adverse events. Lehfilcon A is a recently developed contact lens with a water gradient surface composed of polymeric 2-methacryloyloxyethyl phosphorylcholine (MPC). MPC is re-ported to impart anti-biofouling properties onto modified substrates. Therefore, in this in vitro experimental study, we tested the capability of lehfilcon A to resist adhesion by . Quantitative bacterial adhesion assays using five strains of were conducted to compare the adherence properties of lehfilcon A to five currently marketed silicone hydrogel (SiHy) contact lenses (comfilcon A, fanfilcon A, senofilcon A, senofilcon C, and samfilcon A). Compared to lehfilcon A, we observed 26.7 ± 8.8 times ( = 0.0028) more binding to comfilcon A, 30.0 ± 10.8 times ( = 0.0038) more binding to fanfilcon A, 18.2 ± 6.2 times ( = 0.0034) more binding to senofilcon A, 13.6 ± 3.9 times ( = 0.0019) more binding to senofilcon C, and 29.5 ± 11.8 times ( = 0.0057) more binding to samfilcon A. These results demonstrate that, for various strains of , lehfilcon A reduces bacterial adhesion compared to other contact lens materials.

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