ChAdOx1 NCoV-19 Vaccination Generates Spike-specific CD8 T Cells in Aged Mice

Overview

Journal Immunol Cell Biol

Publisher Wiley

Specialties Allergy & Immunology
Cell Biology

Date 2023 Mar 28

PMID 36975169

Authors

William S Foster

Joseph Newman

Nazia Thakur

Alexandra J Spencer

Sophie Davies

Danielle Woods

Leila Godfrey

Sarah H Ross

Hayley J Sharpe

Arianne C Richard

Dalan Bailey

Teresa Lambe

Michelle A Linterman

Affiliations

Soon will be listed here.

Abstract

Effective vaccines have reduced the morbidity and mortality caused by severe acute respiratory syndrome coronavirus-2 infection; however, the elderly remain the most at risk. Understanding how vaccines generate protective immunity and how these mechanisms change with age is key for informing future vaccine design. Cytotoxic CD8 T cells are important for killing virally infected cells, and vaccines that induce antigen-specific CD8 T cells in addition to humoral immunity provide an extra layer of immune protection. This is particularly important in cases where antibody titers are suboptimal, as can occur in older individuals. Here, we show that in aged mice, spike epitope-specific CD8 T cells are generated in comparable numbers to younger animals after ChAdOx1 nCoV-19 vaccination, although phenotypic differences exist. This demonstrates that ChAdOx1 nCoV-19 elicits a good CD8 T-cell response in older bodies, but that typical age-associated features are evident on these vaccine reactive T cells.

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