Extrachromosomal Amplification of Human Papillomavirus Episomes Is a Mechanism of Cervical Carcinogenesis

Overview

Journal Cancer Res

Specialty Oncology

Date 2023 Mar 27

PMID 36971511

Authors

Nicole M Rossi

Jieqiong Dai

Yi Xie

Darawalee Wangsa

Kerstin Heselmeyer-Haddad

Hong Lou

Joseph F Boland

Meredith Yeager

Roberto Orozco

Enrique Alvirez Freites

Lisa Mirabello

Eduardo Gharzouzi

Michael Dean

Affiliations

Soon will be listed here.

Abstract

Multimers of the HPV genome are generated in cervical tumors replicating as extrachromosomal episomes, which is associated with deletion and rearrangement of the HPV genome and provides a mechanism for oncogenesis without integration.

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