Nanotechnological Strategies to Increase the Oxygen Content of the Tumor

Overview

Journal Front Pharmacol

Date 2023 Mar 27

PMID 36969866

Authors

Junjie Zhang

Kaiyuan Tang

Runqi Fang

Jiaming Liu

Ming Liu

Jiayi Ma

Hui Wang

Meng Ding

Xiaoxiao Wang

Yanni Song

Dongliang Yang

Affiliations

Soon will be listed here.

Abstract

Hypoxia is a negative prognostic indicator of solid tumors, which not only changes the survival state of tumors and increases their invasiveness but also remarkably reduces the sensitivity of tumors to treatments such as radiotherapy, chemotherapy and photodynamic therapy. Thus, developing therapeutic strategies to alleviate tumor hypoxia has recently been considered an extremely valuable target in oncology. In this review, nanotechnological strategies to elevate oxygen levels in tumor therapy in recent years are summarized, including (I) improving the hypoxic tumor microenvironment, (II) oxygen delivery to hypoxic tumors, and (III) oxygen generation in hypoxic tumors. Finally, the challenges and prospects of these nanotechnological strategies for alleviating tumor hypoxia are presented.

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