Pharmaceutical Reactivation of Attenuated Apoptotic Pathways Leads to Elimination of Osimertinib Drug-Tolerant Cells
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Significance: These studies uncover strategies to use targeted agents that activate apoptosis in non-small cell lung cancer cells that survive initial EGFR TKI treatment.
Drug-tolerant persister cancer cells.
Wang P, Ke B, Ma G J Natl Cancer Cent. 2024; 4(1):1-5.
PMID: 39036383 PMC: 11256673. DOI: 10.1016/j.jncc.2023.12.002.
Izumi M, Costa D, Kobayashi S Lung Cancer. 2024; 194:107885.
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Diapause-like Drug-Tolerant Persister State: The Key to Nirvana Rebirth.
Chen H, Jin W Medicina (Kaunas). 2024; 60(2).
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