Article: Unraveling the roles of cerebrospinal fluid-contacting neurons

Sensory neurons previously shown to optimize speed and balance in fish by providing information about the curvature of the spine show similar morphology and connectivity in mice.

Citing Articles

The neurobiology of interoception and affect.

Feldman M, Bliss-Moreau E, Lindquist K Trends Cogn Sci. 2024; 28(7):643-661.

PMID: 38395706 PMC: 11222051. DOI: 10.1016/j.tics.2024.01.009.

SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation.

Xu H, Dugue G, Cantaut-Belarif Y, Lejeune F, Gupta S, Wyart C Fluids Barriers CNS. 2023; 20(1):89.

PMID: 38049798 PMC: 10696872. DOI: 10.1186/s12987-023-00491-8.

A Comparison of PKD2L1-Expressing Cerebrospinal Fluid Contacting Neurons in Spinal Cords of Rodents, Carnivores, and Primates.

Liu X, Rich K, Nasseri S, Li G, Hjaeresen S, Finsen B Int J Mol Sci. 2023; 24(17).

PMID: 37686387 PMC: 10488076. DOI: 10.3390/ijms241713582.

References

1.

Bohm U, Prendergast A, Djenoune L, Figueiredo S, Gomez J, Stokes C . CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits. Nat Commun. 2016; 7:10866. PMC: 4786674. DOI: 10.1038/ncomms10866. View

2.

Djenoune L, Khabou H, Joubert F, Quan F, Figueiredo S, Bodineau L . Investigation of spinal cerebrospinal fluid-contacting neurons expressing PKD2L1: evidence for a conserved system from fish to primates. Front Neuroanat. 2014; 8:26. PMC: 4018565. DOI: 10.3389/fnana.2014.00026. View

3.

Orts-DelImmagine A, Cantaut-Belarif Y, Thouvenin O, Roussel J, Baskaran A, Langui D . Sensory Neurons Contacting the Cerebrospinal Fluid Require the Reissner Fiber to Detect Spinal Curvature In Vivo. Curr Biol. 2020; 30(5):827-839.e4. DOI: 10.1016/j.cub.2019.12.071. View

4.

Wu M, Carbo-Tano M, Mirat O, Lejeune F, Roussel J, Quan F . Spinal sensory neurons project onto the hindbrain to stabilize posture and enhance locomotor speed. Curr Biol. 2021; 31(15):3315-3329.e5. DOI: 10.1016/j.cub.2021.05.042. View

5.

Gerstmann K, Jurcic N, Blasco E, Kunz S, de Almeida Sassi F, Wanaverbecq N . The role of intraspinal sensory neurons in the control of quadrupedal locomotion. Curr Biol. 2022; 32(11):2442-2453.e4. DOI: 10.1016/j.cub.2022.04.019. View

6.

ECCLES J, Sherrington C . Reflex summation in the ipsilateral spinal flexion reflex. J Physiol. 1930; 69(1):1-28. PMC: 1402942. DOI: 10.1113/jphysiol.1930.sp002630. View

7.

Jalalvand E, Robertson B, Wallen P, Grillner S . Ciliated neurons lining the central canal sense both fluid movement and pH through ASIC3. Nat Commun. 2016; 7:10002. PMC: 4729841. DOI: 10.1038/ncomms10002. View

8.

Nakamura Y, Kurabe M, Matsumoto M, Sato T, Miyashita S, Hoshina K . Cerebrospinal fluid-contacting neuron tracing reveals structural and functional connectivity for locomotion in the mouse spinal cord. Elife. 2023; 12. PMC: 9943067. DOI: 10.7554/eLife.83108. View

9.

Sternberg J, Prendergast A, Brosse L, Cantaut-Belarif Y, Thouvenin O, Orts-DelImmagine A . Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature. Nat Commun. 2018; 9(1):3804. PMC: 6143598. DOI: 10.1038/s41467-018-06225-x. View

10.

Wyart C, Del Bene F, Warp E, Scott E, Trauner D, Baier H . Optogenetic dissection of a behavioural module in the vertebrate spinal cord. Nature. 2009; 461(7262):407-10. PMC: 2770190. DOI: 10.1038/nature08323. View

11.

Hubbard J, Bohm U, Prendergast A, Tseng P, Newman M, Stokes C . Intraspinal Sensory Neurons Provide Powerful Inhibition to Motor Circuits Ensuring Postural Control during Locomotion. Curr Biol. 2016; 26(21):2841-2853. DOI: 10.1016/j.cub.2016.08.026. View

Unraveling the Roles of Cerebrospinal Fluid-contacting Neurons